Vericiguat ni apyrazolopyridinenibyo5-fluoro-1H-pyrazolo [3,4-b] pyridinemuribwo hydrogène amino kumwanya wa 1 yasimbujwe nitsinda rya 2-fluorobenzyl nahydrogenkumwanya wa 3 wasimbuwe na 4,6-diamino-5 - [(mikorerexycarbonyl) amino] pyrimidin-2-yl itsinda. Nibishobora gukemukaguanylatecyclase stimulator ikoreshwa mukuvura kunanirwa k'umutima karande. Ifite uruhare rwo gukemuraguanylateUmukoresha wa cyclase, umukozi wa vasodilator hamwe na antivypertensive agent. Ni anaminopyrimidine, apyrazolopyridine, ester ya karbamate hamwe na organofluorine.

Vericiguat iri gukorwaho iperereza mu igeragezwa ry’amavuriro NCT02861534 (Ubushakashatsi bwakozwe na Vericiguat mu bitabiriye amahugurwa bafite ikibazo cyo kunanirwa k'umutima hamwe no kugabanya igice cyo gusohora (HFrEF) (MK-1242-001)).

Vericiguat ni IgisubizoGuanylateUmukino wa Cyclase. Uburyo bwibikorwa bya vericiguat ni nka aGuanylateUmukino wa Cyclase.

Vericiguat ni imiti ikoreshwa mu gucunga no kuvura kunanirwa k'umutima hamwe no kugabanya igice cyo gusohora (HFrEF). Ningirakamaro kuburwayi bwumutima budakira, kunanirwa k'umutima vuba. Vericiguat ntabwo yongerera ubuzima ariko irinda ibitaro. Iki gikorwa kigaragaza ibimenyetso, uburyo bwibikorwa, igipimo, nuburyo bwo kuyobora nitsinda ryabasobanuzi, ingaruka mbi, kwanduza, hamwe nibigeragezo byinshi kugirango bishyigikire ibimenyetso byerekana akamaro k'ibiyobyabwenge muri HFrEF.