Amavu n'amavuko

Agomelatine ni agoniste ya reseptor ya melatonin na antagonist ya reseptor ya serotonine 5-HT2C ifite agaciro ka 0.062nM na 0.268nM na IC50 agaciro ka 0.27μM, kuri MT1, MT2 na 5-HT2C [1].

Agomelatine ni antidepressant idasanzwe kandi yatejwe imbere yo kuvura indwara zikomeye zo kwiheba (MDD).Agomelatine ihitamo kurwanya 5-HT2C.Irerekana isano rito kubantu bakoronijwe 5-HT2A na 5-HT1A.Kubakira melatonin, agomelatine yerekana isano isa na MT1 na MT2 ya clone ifite agaciro ka 0.09nM na 0.263nM.Mu bushakashatsi bwa vivo, agomelatine itera kwiyongera kwa dopamine na noradrenaline binyuze mukubuza kwinjiza 5-HT2C.Byongeye kandi, imiyoborere ya agomelatine irwanya kugabanuka guterwa no kugabanuka kwa kurya kwa sucrose muburyo bwimbeba yo kwiheba.Uretse ibyo, agomelatine igabanya imbaraga zo guhangayika muburyo bwo guhangayika [1].

Reba:
[1] Zupancic M, Guilleminault C. Agomelatine.Ibiyobyabwenge bya CNS, 2006, 20 (12): 981-992.

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