Amavu n'amavuko

Citrate ya Tofacitinib, izwi kandi nka CP-690550 citrate, ni ikintu gikomeye kibuza janus kinase 3 (JAK3), indwara ya hematopoetic selile yagabanijwe na tyrosine kinase igira uruhare mu kwanduza ibimenyetso bigenga lymphocyte kubaho, gukwirakwizwa, gutandukanya, na apoptose.Kubuzwa ni JAK3 yihariye hamwe no guhitamo inshuro 1000 kurenza iyindi miryango itari JAK.Usibye kubuza JAKS (IC50 = 1 nM), citrate ya tofacitinib inabuza janus kinase 2 (JAK2) na janus kinase 1 (JAK1) hamwe na 20- na 100 munsi yububasha.Nyamara, mu bushakashatsi buherutse gukorwa, guhuza isano (Ki) ya tofacitinib citrate yerekeza kuri JAK1, JAK2, na JAK3 byavuzwe ko ari 1.6 nM, 21.7 nM, na 6.5 nM.

Reba

Lalitha Vijayakrishnan, R. Venkataramanan na Palak Gulati.Kuvura umuriro hamwe na janus kinase inhibitor CP-690,550.Imigendekere yubumenyi bwa farumasi 2011: 32 (1);25-34

Ibicuruzwa byatanzwe

• 1. Panagi I, Jennings E, n'abandi..Microbe yakira selile.2020; 27 (1): 41–53.e6.PMID: 31862381
• 2. McInnes IB, Byers NL, n'abandi."Kugereranya baricitinib, upadacitinib, na tofacitinib byahujwe no kugenzura ibimenyetso bya cytokine mu bantu ba leukocyte."Indwara ya rubagimpande.2019 Kanama 2; 21 (1): 183.PMID: 31375130
• 3. Liu S, Verma M, n'abandi..2018 Mutarama; 141 (1): 257-268.e6.PMID: 28433687
• 4. Zheng, Lufeng, n'abandi."3 ′ UTR ya pseudogene CYP4Z2P itera ikibyimba angiogenez muri kanseri y'ibere ikora nka ceRNA kuri CYP4Z1."Ubushakashatsi no kuvura kanseri y'ibere (2015): 1-14.PMID: 25701119

Ibisobanuro

Tofacitinib citrate ni munzira iboneka ya JAK1 / 2/3 hamwe na IC50s ya 1, 20, na 112 nM.Citrate ya Tofacitinib ifite antibacterial, antifungal na virusi.

Ububiko

4 ° C, urinde urumuri

* Mubisubizo: -80 ° C, amezi 6;-20 ° C, ukwezi 1 (kurinda urumuri)

Imiterere yimiti

Bifitanye isano na Biologiya

Bifitanye isano na Biologiya

Bifitanye isano na Biologiya

Bifitanye isano na Biologiya

Bifitanye isano na Biologiya