Ibisobanuro

Sugammadex sodium ni intungamubiri γ-cyclodextrin ikomoka, kandi ikora nkibintu bishya bihindura imitsi ya neuromuscular.

Izina rusange: sugammadex (soo GAM ma dex)
Izina ryirango: Umugeni

Sugammadex ihindura ingaruka zimiti imwe nimwe itangwa mugihe cyo kubaga kugirango woroshye imitsi.

Sugammadex ikoreshwa nyuma yo kubagwa, kugirango ifashe kugarura imikorere yimitsi yahagaritswe mugihe cyo kubagwa nindi miti.

Sugammadex irashobora kandi gukoreshwa kubintu bitashyizwe kurutonde rwimiti.

Ikoreshwa muguhindura ingaruka zibiyobyabwenge.

Muri Vivo

Gutera sugammadex nta ngaruka zikomeye bigira ku muvuduko w'amaraso cyangwa ku mutima.Nyuma yo gutera inshinge nyinshi za rocuronium, kugarura 90% ya gari ya moshi-ya-bine bifata min 28 (SD 7 min) nyuma yumunyu, 26 min (SD 9.5 min) nyuma ya mg / kg sugammadex, na 8 min (SD 3.6 min) nyuma ya 2,5 mg / kg sugammadex [1].Sugammadex itera ihinduka ryihuse kandi ryuzuye rya rocuronium iterwa na neuromuscular.Igihe cyo gukira cyo gutoza ibipimo bine = 0.9 nyuma yo gukira bidatinze ni 14.4 min (SD = 3.4 min; n = 14).Ibi byagabanutse cyane kugeza kuri 3.7 min (SD = 3,3 min; n = 4) hamwe na sugammadex 0.5 mg / kg no kuri min 1.9 (SD = 1.0 min; n = 4) hamwe na sugammadex 1.0 mg / kg [2].Ikigereranyo cya kimwe cya kabiri cyubuzima bwa sugammadex muri monkey ya Rhesus ni 30 (SEM = 4.9) min [3].

Ububiko

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