Ibisobanuro

Sugammadex sodium ni intungamubiri γ-cyclodextrin ikomoka, kandi ikora nkibintu bishya bihindura imitsi ya neuromuscular.

Izina rusange: sugammadex (soo GAM ma dex)
Izina ry'ikirango: Umugeni

Sugammadex ihindura ingaruka z'imiti imwe n'imwe itangwa mugihe cyo kubaga kugirango woroshye imitsi.

Sugammadex ikoreshwa nyuma yo kubagwa, kugirango ifashe kugarura imikorere yimitsi yahagaritswe mugihe cyo kubagwa nindi miti.

Sugammadex irashobora kandi gukoreshwa kubintu bitashyizwe kurutonde rwiki gitabo.

Ikoreshwa muguhindura ingaruka zibiyobyabwenge.

Muri Vivo

Gutera sugammadex nta ngaruka zikomeye bigira ku muvuduko w'amaraso cyangwa ku mutima. Nyuma yo gutera inshinge nyinshi za rocuronium, 90% yo kugarura gari ya moshi-ya-bine bifata min 28 (SD 7 min) nyuma yumunyu, min 26 (SD 9.5 min) nyuma ya mg / kg 1 mg / kg sugammadex, na 8 min (SD 3.6 min) nyuma ya 2,5 mg / kg sugammadex [1]. Sugammadex itera ihinduka ryihuse kandi ryuzuye rya rocuronium iterwa na neuromuscular. Igihe cyo gukira cyo kwitoza ibipimo bine = 0.9 nyuma yo gukira bidatinze ni 14.4 min (SD = 3.4 min; n = 14). Ibi byagabanutse cyane kugeza kuri 3.7 min (SD = 3,3 min; n = 4) hamwe na sugammadex 0.5 mg / kg no kuri min 1.9 (SD = 1.0 min; n = 4) hamwe na sugammadex 1.0 mg / kg [2]. Ikigereranyo cya kabiri cyubuzima bwa sugammadex muri monkey ya Rhesus ni 30 (SEM = 4.9) min [3].

Ububiko

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