Sacubitril Hemicalcium
沙 库 比 曲 钙盐 | Sacubitril Hemicalcium | 1369773-39-6 | Mu nzu |
沙 库 比 曲 钠盐 | 149690-05-1 | Mu nzu | |
LCZ-4 | 1426129-50-1 | Mu nzu | |
LCZ-7 | 1012341-48-8 | Mu nzu | |
LCZ-8 | 1012341-50-2 | Mu nzu | |
LCZ-9 | 149690-12-0 | Mu nzu |
Amavu n'amavuko
Umunyu wa AHU-377 ni umunyu wa hemicalcium yumunyu wa AHU-377.Ni inhibitori ya neprilysin ifite IC50 agaciro ka 5 nM [1].
AHU-377 hamwe na angiotensin II AT1 reseptor antagonist valsartan bahimba LCZ696 mukigereranyo cya 1: 1.LCZ696 ni reseptor ya angiotensin neprilysin inhibitor.Irashobora kugabanya umuvuduko wamaraso kandi irashobora kuba imiti mishya yo kuvura kunanirwa k'umutima.AHU-377 ni ibiyobyabwenge, birashobora guhindurwa na enzymatique clavage ya Ethyl ester muburyo bukora LBQ657.Biravugwa ko AHU-377 (30 na 100 mg / kg, PO) ishobora gutera antivypertensique mu buryo bushingiye ku mbeba ya DAHI-SS.Ariko muri imbeba ya hypertension ya DOCA-umunyu, irerekana kugabanuka guke [2, 3].
Reba:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic aside dipeptide itabogamye ya endopeptidase.J Med Chem.1995 Gicurasi 12;38 (10): 1689-700.
[2] Amajwi AA, Dorhout B, van der Meer P. Uruhare rushoboka rwa valsartan + AHU377 (LCZ696) mukuvura kunanirwa k'umutima.Impuguke Opin Iperereza Ibiyobyabwenge.2013 Kanama; 22 (8): 1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi n'abandi.Kugereranya efficacy ya AHU-377, inhibitor ikomeye ya neprilysin, muburyo bubiri bwimbeba ya hypertension.Imiti ya BMC 2011, 11 (Umugereka 1): P33.
Imiterere yimiti
Icyifuzo18Imishinga yo gusuzuma ireme ryemejwe4, na6imishinga iremezwa.
Sisitemu mpuzamahanga yo gucunga neza ubuziranenge yashyizeho urufatiro rukomeye rwo kugurisha.
Igenzura ryiza rinyura mubuzima bwose bwibicuruzwa kugirango hamenyekane ingaruka nziza nubuvuzi.
Itsinda ryumwuga ushinzwe kugenzura ibikorwa byujuje ubuziranenge mugihe cyo gusaba no kwiyandikisha.