Sacubitril Hemicalcium
沙 库 比 曲 钙盐 | Sacubitril Hemicalcium | 1369773-39-6 | Mu nzu |
沙 库 比 曲 钠盐 | 149690-05-1 | Mu nzu | |
LCZ-4 | 1426129-50-1 | Mu nzu | |
LCZ-7 | 1012341-48-8 | Mu nzu | |
LCZ-8 | 1012341-50-2 | Mu nzu | |
LCZ-9 | 149690-12-0 | Mu nzu |
Amavu n'amavuko
Umunyu wa AHU-377 ni umunyu wa hemicalcium yumunyu wa AHU-377.Ni inhibitori ya neprilysin ifite IC50 agaciro ka 5 nM [1].
AHU-377 hamwe na angiotensin II AT1 reseptor antagonist valsartan bahimba LCZ696 mukigereranyo cya 1: 1.LCZ696 ni reseptor ya angiotensin neprilysin inhibitor.Irashobora kugabanya umuvuduko wamaraso kandi irashobora kuba imiti mishya yo kuvura kunanirwa k'umutima.AHU-377 ni ibiyobyabwenge, birashobora guhindurwa na enzymatique clavage ya Ethyl ester muburyo bukora LBQ657.Biravugwa ko AHU-377 (30 na 100 mg / kg, PO) ishobora gutera antivypertensique mu buryo bushingiye ku mbeba ya DAHI-SS.Ariko muri imbeba ya hypertension ya DOCA-umunyu, irerekana kugabanuka guke [2, 3].
Reba:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic aside dipeptide itabogamye ya endopeptidase.J Med Chem.1995 Gicurasi 12;38 (10): 1689-700.
[2] Amajwi AA, Dorhout B, van der Meer P. Uruhare rushoboka rwa valsartan + AHU377 (LCZ696) mukuvura kunanirwa k'umutima.Impuguke Opin Iperereza Ibiyobyabwenge.2013 Kanama; 22 (8): 1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi n'abandi.Kugereranya efficacy ya AHU-377, inhibitor ikomeye ya neprilysin, muburyo bubiri bwimbeba ya hypertension.Imiti ya BMC 2011, 11 (Umugereka 1): P33.
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