Amavu n'amavuko

Umunyu wa AHU-377 ni umunyu wa hemicalcium umunyu wa AHU-377. Nibibuza neprilysine ifite IC50 agaciro ka 5 nM [1].

AHU-377 hamwe na angiotensin II AT1 reseptor antagonist valsartan bahimba LCZ696 mukigereranyo cya 1: 1. LCZ696 ni reseptor ya angiotensin neprilysin inhibitor. Irashobora kugabanya umuvuduko wamaraso kandi irashobora kuba imiti mishya yo kuvura kunanirwa k'umutima. AHU-377 ni ibiyobyabwenge, birashobora guhindurwa na enzymatique clavage ya Ethyl ester muburyo bukora LBQ657. Biravugwa ko AHU-377 (30 na 100 mg / kg, PO) ishobora gutera ingaruka ziterwa na antivypertensique mu buryo buterwa na dose mu mbeba za DAHI-SS. Ariko muri imbeba ya hypertension ya DOCA-umunyu, irerekana kugabanuka guke [2, 3].

Reba:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acide dipeptide itabogamye ya endopeptidase. J Med Chem. 1995 Gicurasi 12; 38 (10): 1689-700.
[2] Amajwi AA, Dorhout B, van der Meer P. Uruhare rushoboka rwa valsartan + AHU377 (LCZ696) mukuvura kunanirwa k'umutima. Impuguke Opin Iperereza Ibiyobyabwenge. 2013 Kanama; 22 (8): 1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi n'abandi. Kugereranya efficacy ya AHU-377, inhibitor ikomeye ya neprilysin, muburyo bubiri bwimbeba ya hypertension. Farumasi ya BMC 2011, 11 (Umugereka 1): P33.

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