GIzina ryimbaraga:venetoclax (ven ET yewe klax)
Izina ry'ikirango: Venclexta, Venclexta Gutangira

Venetoclax ikoreshwa mu kuvura indwara ya lymphocytike idakira cyangwa lymphocytike ntoya.Venetoclax ikoreshwa wenyine cyangwa ifatanije nindi miti ya kanseri kugirango ivure ibi bihe.

Venetoclax ikoreshwa ifatanije na azacitidine, decitabine, cyangwa cytarabine mu kuvura indwara ya myeloid ikaze.Uku guhuriza hamwe ni ugukoresha mubantu bakuru bafite imyaka 75 cyangwa irenga, cyangwa badashobora gukoresha chimiotherapie isanzwe kubera ubundi burwayi.

Venetoclax rimwe na rimwe itangwa nyuma yubuvuzi bwananiranye.

Venetoclax irashobora kandi gukoreshwa mubikorwa bitashyizwe kurutonde rwimiti.

Ibisobanuro

Venetoclax (ABT-199; GDC-0199) ni imbaraga zikomeye, zitoranya kandi zikoresha bioavailable Bcl-2 inhibitor hamwe na Ki iri munsi ya 0.01 nM.Venetoclax itera autophagy.

Muri Vitro

Venetoclax (ABT-199) yica cyane selile FL5.12-BCL-2 (EC50 = 4 nM), Venetoclax (ABT-199) yerekana ibikorwa bidakomeye kurwanya selile FL5.12-BCL-XL (EC50 = 261 nM).ABT-199 irerekana kandi guhitamo mubikoko by’inyamabere ebyiri-bivangavanze, aho bihungabanya inganda za BCL-2-BIM (EC50 = 3 nM) ariko ntibikora neza kurwanya BCL-XL-BCL-XS (EC50 = 2.2μM) cyangwa MCL-1-NOXA.

Nyuma yo kunywa umunwa umwe wa 12,5 mg kuri kg uburemere bwumubiri muri xenografts ikomoka kuri RS4; selile 11 (BYOSE), Venetoclax (ABT-199) itera ikura ryinshi ryikibyimba (TGImax) cya 47% (P <0.001) no gukura kwikibyimba gutinda (TGD) ya 26% (P <0.05) [1].

Kuvura ibishushanyo mbonera byashizweho (imbeba xenograft yerekana ibibyimba bya T-BYOSE umurongo wa LOUCY) hamwe na Venetoclax (ABT-199) 100 mg / kg muminsi 4 bivamo kugabanya cyane umutwaro wa leukemic.