Ibisobanuro

Kalisiyumu ya Rosuvastatin (BANM, JAN, USAN) izwi nka Rosuvastatin muri Amerika. hamwe na HMG-CoA irwanya reductase inhibitor hamwe na IC50 ya 11 nM [1]. Kalisiyumu ya Rosuvastatin ihagarika cyane imbaraga za ether-a-go-go zijyanye na gene (HERG) hamwe na IC50 ya 195 nM, gutinda kwongera umutima, bityo bigatuma ibikorwa bishobora kumara igihe kirekire (APDs) kandi bikosora intera ya QT (QTc) [2]. Kalisiyumu ya Rosuvastatin igabanya imvugo ya HERG ikuze no gukorana kwa poroteyine yubushyuhe 70 (Hsp70) hamwe na poroteyine ya HERG. Kalisiyumu ya Rosuvastatin igira akamaro kanini mu kugabanya cholesterol ya lipoproteine ​​(LDL) nkeya, triglyceride, na poroteyine C-itera imbaraga [3].

Andi makuru yerekeye amasezerano yo kwita ibiyobyabwenge: Amazina mpuzamahanga adaharanira inyungu.

Icyitonderwa cyingenzi: Ububiko mpuzamahanga bwibiyobyabwenge biri mubisohoka BETA. Ibi bivuze ko ikiri mu majyambere kandi irashobora kuba irimo amakosa. Ntabwo igenewe gusimburwa nubuhanga no guca urubanza kwa muganga, umufarumasiye cyangwa undi muntu winzobere mubuzima. Ntibikwiye kumvikana kwerekana ko gukoresha imiti iyo ari yo yose mu gihugu icyo ari cyo cyose bifite umutekano, bikwiye cyangwa byiza kuri wewe. Baza inzobere mu buvuzi mbere yo gufata imiti iyo ari yo yose.

Muri Amerika, Rosuvastatin (sisitemu ya rosuvastatin) ni umunyamuryango wa statine yo mu rwego rw’ibiyobyabwenge kandi ikoreshwa mu kuvura Atherosclerose, Cholesterol Yisumbuye, Cholesterol - Heterozygous Familial, Cholesterol - Familial Homozygous, Hyperlipoproteinemia, Hyperlipoproteinemia Type Hyperlipoproteinemia IIb - Kuzamura LDL VLDL, Hyperlipoproteinemia Ubwoko bwa III - Hejuru ya beta-VLDL IDL, Hyperlipoproteinemia Ubwoko bwa IV - VLDL, Hypertriglyceridemia no kwirinda indwara zifata umutima.

Amavu n'amavuko

Guhitamo guhitamo, guhatanira HMG-CoA reductase, ibyo nabyo birwanya antilipemic.

Ububiko

Imiterere yimiti