Ibisobanuro

Kalisiyumu ya Rosuvastatin (BANM, JAN, USAN) izwi nka Rosuvastatin muri Amerika.hamwe na HMG-CoA irwanya reductase inhibitor hamwe na IC50 ya 11 nM [1].Kalisiyumu ya Rosuvastatin ihagarika imbaraga za ether-yumuntu ujyanye na gene (HERG) hamwe na IC50 ya 195 nM, gutinda kwimitsi yumutima, bityo bigatuma ibikorwa byigihe kirekire (APDs) bikosora intera ya QT (QTc) [2].Kalisiyumu ya Rosuvastatin igabanya imvugo ya HERG ikuze no gukorana kwa poroteyine yubushyuhe 70 (Hsp70) hamwe na poroteyine ya HERG.Kalisiyumu ya Rosuvastatin igira akamaro kanini mu kugabanya cholesterol ya lipoproteine ​​(LDL) nkeya, triglyceride, hamwe na poroteyine C-itera imbaraga [3].

Andi makuru yerekeye amasezerano yo kwita ibiyobyabwenge: Amazina Mpuzamahanga.

Icyitonderwa cyingenzi: Ububiko mpuzamahanga bwibiyobyabwenge biri mubisohoka BETA.Ibi bivuze ko bikiri mu majyambere kandi birashobora kuba birimo amakosa.Ntabwo igenewe gusimburwa nubuhanga no guca imanza kwa muganga, umufarumasiye cyangwa undi mwuga wubuzima.Ntibikwiye kumvikana kwerekana ko gukoresha imiti iyo ari yo yose mugihugu icyo aricyo cyose bifite umutekano, bikwiye cyangwa byiza kuri wewe.Baza inzobere mu buvuzi mbere yo gufata imiti iyo ari yo yose.

Muri Amerika, Rosuvastatin (sisitemu ya rosuvastatin) ni umunyamuryango wa statin yo mu rwego rw’ibiyobyabwenge kandi ikoreshwa mu kuvura Atherosclerose, Cholesterol, Cholesterol - Heterozygous Familial, Cholesterol - Familial Homozygous, Hyperlipoproteinemia, Hyperlipoproteinemia Hyperlipoproteinemia IIb - Kuzamura LDL VLDL, Hyperlipoproteinemia Ubwoko bwa III - Hejuru ya beta-VLDL IDL, Hyperlipoproteinemia Ubwoko bwa IV - VLDL, Hypertriglyceridemia no Kurinda Indwara z'umutima.

Amavu n'amavuko

Guhitamo, guhatanira inhibitori ya HMG-CoA reductase, ibyo nabyo birwanya antilipemic.

Ububiko

Imiterere yimiti