Ubushinwa Pitavastatin Kalisiyumu ikora nabatanga |CPF

Kalisiyumu ya Pitavastatin

Ibisobanuro bigufi:

Izina rya API	Kwerekana	Ibisobanuro	DMF yo muri Amerika	EU DMF	CEP
Kalisiyumu ya Pitavastatin	Hypercholesterolemia	Mu nzu

Ohereza imeri kuri twe

Ibisobanuro birambuye

Ibiranga ibicuruzwa

KUBONA UMUSARURO

匹伐他汀钙	Pitavastatin	147526-32-7	Mu nzu
PI-5		3800-06-4	Mu nzu
PI-6		145516-11-4	Mu nzu
PI-7		121660-11-5	Mu nzu

Ibisobanuro

Kalisiyumu ya Pitavastatine (NK-104 hemicalcium) ni hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor.Kalisiyumu ya Pitavastatine (NK-104 hemicalcium) ibuza synthesis ya cholesterol kuva acide acetike hamwe na IC50 ya 5.8 nM muri selile HepG2.Kalisiyumu ya Pitavastatine ni hepatocyte ikora neza ya lipoprotein-cholesterol (LDL-C) reseptor inducer.Igikorwa cyo kurwanya kanseri.

Amavu n'amavuko

Kalisiyumu ya Pitavastatine ni irwanya irwanya enzyme HMGCR (HMG-CoA reductase) bivamo kugabanuka kwa LDL ya cholesterol.Ubundi bushakashatsi bwerekana ko pitavastatine ishobora guhagarika umusaruro wa ogisijeni mu ngirabuzimafatizo ya NADPH.Byongeye kandi, pitavastatin igabanya imvugo ya eNOS mRNA mugihe yongerera OYA igisubizo giterwa na acetylcholine na calcium ionophore, A23187.Byongeye kandi, pitavastatin irabuza kugenzura-imiyoboro ya calcium ikora ya potasiyumu igabanya urugero rwa cholesterol mu ngirabuzimafatizo.

Ububiko

4°C, urinde urumuri

* Mubisubizo: -80°C, amezi 6;-20°C, ukwezi 1 (kurinda urumuri)

Imiterere yimiti

Pitavastatin Calcium