Pomalidomide, mbere izwi nka CC-4047 cyangwa actimid, ni molekile ikomeye ikingira immunomodulatory yerekana ibikorwa bya antineoplastique yo kuvura indwara mbi ziterwa na hematologiya, cyane cyane yisubiramo kandi yanga myeloma myinshi (MM). Nkibikomoka kuri thalidomide, pomalidomide ifite imiterere yimiti isa na thalidomide usibye kongeramo amatsinda abiri ya oxo mumpeta ya phthaloyl hamwe nitsinda rya amino kumwanya wa kane. Mubisanzwe, nka molekile ikingira indwara, pomalidomide yerekana ibikorwa bya antitumor ikoresheje uburyo bwo guhagarika microen ibidukikije yibibyimba hifashishijwe cytokine itera ibibyimba (TNF-α, IL-6, IL-8 na VEGF), igenzura neza imikorere yingenzi yibibyimba selile, hamwe no gushigikira infashanyo zitari immunite host selile.

Pomalidomide ikoreshwa mu kuvura myeloma myinshi (kanseri ituruka ku ndwara y'amaraso igenda itera imbere). Ubusanzwe Pomalidomide itangwa nyuma byibuze byibuze indi miti ibiri yageragejwe nta ntsinzi.

Pomalidomide nayo ikoreshwa mu kuvura sida ya Kaposi sarcoma iterwa na sida mugihe indi miti idakora cyangwa yahagaritse gukora. pomalidomide irashobora kandi gukoreshwa mukuvura Kaposi Sarcoma mubantu bakuru bariVIH-negative.

Pomalidomide iraboneka gusa muri farumasi yemewe muri gahunda idasanzwe. Ugomba kwiyandikisha muri gahunda kandi ukemera gukoreshakuringaniza imbyaroingamba nkuko bisabwa.

Pomalidomide irashobora kandi gukoreshwa kumpamvu zitanditswe muriki gitabo cyimiti.

Pomalidomide irashobora gutera ubumuga bukomeye, bwangiza ubuzima cyangwa urupfu rwumwana mugihe nyina cyangwa se bafata pomalidomide mugihe cyo gusama cyangwa mugihe cyo gutwita. Ndetse ikinini kimwe cya pomalidomide kirashobora gutera inenge zikomeye zamaboko namaguru yumwana, amagufwa, ugutwi, amaso, mumaso, numutima. Ntuzigere ukoresha pomalidomide niba utwite. Bwira muganga wawe ako kanya niba imihango yawe yatinze mugihe ufata pomalidomide.