Ibisobanuro

Kalisiyumu ya Pitavastatine (NK-104 hemicalcium) ni hydroxymethylglutaryl-CoA (HMG-CoA) inhibitor. Kalisiyumu ya Pitavastatine (NK-104 hemicalcium) ibuza synthesis ya cholesterol ikomoka kuri acide acike hamwe na IC50 ya 5.8 nM muri selile HepG2. Kalisiyumu ya Pitavastatine ni hepatocyte ikora neza ya lipoprotein-cholesterol (LDL-C) inducer. Igikorwa cyo kurwanya kanseri.

Amavu n'amavuko

Kalisiyumu ya Pitavastatin ni inzitizi irwanya enzyme HMGCR (HMG-CoA reductase) itera kugabanuka kwa LDL ya cholesterol. Ubundi bushakashatsi bwerekana ko pitavastatine ishobora guhagarika umusaruro wa ogisijeni mu ngirabuzimafatizo ya endothelia mu kubuza okiside ya NADPH. Byongeye kandi, pitavastatin igabanya imvugo ya eNOS mRNA mugihe yongerera OYA igisubizo giterwa na acetylcholine na calcium ionophore, A23187. Byongeye kandi, pitavastatin ibuza kugenzura-imiyoboro ya calcium ikoreshwa na potasiyumu ya calcium igabanya urugero rwa cholesterol mu ngirabuzimafatizo.

Ububiko

4°C, urinde urumuri

* Mubisubizo: -80°C, amezi 6; -20°C, ukwezi 1 (kurinda urumuri)

Imiterere yimiti

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