Ibisobanuro

Lenalidomide (CC-5013) ni inkomoko ya Thalidomide hamwe na immunomodulator ikora mu kanwa.Lenalidomide (CC-5013) ni ligand ya ubiquitin E3 ligase cereblon (CRBN), kandi itera guhitamo ahantu hose no gutesha agaciro ibintu bibiri byandikirwa lymphoide, IKZF1 na IKZF3, na CRBN-CRL4 ubiquitin ligase.Lenalidomide (CC-5013) ibuza cyane gukura kwa lymphoma B ikuze, harimo na myeloma myinshi, kandi itera IL-2 kurekura selile.

Amavu n'amavuko

Lenalidomide (izwi kandi nka CC-5013), ikomoka mu kanwa ka thalidomide, ni antineoplastique yerekana ibikorwa bya antitumor hakoreshejwe uburyo butandukanye, harimo gukora sisitemu yumubiri, kubuza angiogenezi, hamwe ningaruka za antineoplastique.Yakozweho ubushakashatsi bwimbitse bwo kuvura indwara ya myeloma na myelodysplastic syndrome hamwe na lymphoproliferative disorders zirimo lymphocytic leukemia idakira (CLL) na lymphoma itari Hodgkin.Nk’uko ubushakashatsi buherutse gukorwa bubigaragaza, Lnalidomide iteza imbere kandi igarura imikorere y’umubiri ku barwayi ba CLL itera gukabya gukabije kwa molekile ya Costimulatory muri lymphocytes ya leukemic kugira ngo igarure ubudahangarwa bw’urwenya hamwe n’umusemburo wa immunoglobuline ndetse no kunoza ubushobozi bw’uturemangingo T na selile zo mu bwoko bwa leukemique. lymphocytes.

Reba

Ana Pilar Gonzalez-Rodriguez, Angel R. Payer, Andrea Acebes-Huerta, Leticia Hergo-Zapico, Monica Villa-Alvarez, Esther Gonzalez-Garcia, na Segundo Gonzalez.Lenalidomide na lymphocytike idakira.BioMed Ubushakashatsi Mpuzamahanga 2013.

Muri Vitro

Lenalidomide ifite imbaraga mukuzamura T selile ikwirakwizwa na IFN-γ n'umusaruro wa IL-2.Lenalidomide yerekanwe kubuza umusaruro wa cytokine pro inflammatory TNF-α, IL-1, IL-6, IL-12 no kuzamura umusaruro wa cytokine anti-inflammatory IL-10 kuva PBMCs zabantu.Lenalidomide igabanya umusaruro wa IL-6 mu buryo butaziguye kandi ikanabuza selile nyinshi za myeloma (MM) hamwe n’imitsi yo mu magufa (BMSC), ibyo bikaba byongera apoptose ya myeloma [2].Imikoreshereze yimikoreshereze yimikorere ya CRBN-DDB1 igaragara hamwe na Thalidomide, Lenalidomide na Pomalidomide, hamwe na IC50 agaciro ka ~ 30μM, ~ 3μM na ~ 3μM.μM [3].Lenalidomide, igereranya rya thalidomide, ikora nka kole ya molekile hagati yumuntu E3 ubiquitin ligase cereblon na CKIα irerekanwa kugirango itere hose kandi itesha agaciro iyi kinase, bityo rero birashoboka ko yica selile leukemic ukoresheje p53.

Uburozi bwa Lenalidomide bugera kuri 15, 22.5, na 45 mg / kg ukoresheje inzira ya IV, IP, na PO.Bitewe no gukemuka mumodoka yacu ya PBS, iyi dosiye ntarengwa ishobora kugerwaho na Lenalidomide usibye urupfu rwimbeba imwe (ya bane yuzuye) kuri 15 mg / kg IV.Ikigaragara ni uko nta bundi burozi bugaragara mu bushakashatsi kuri dosiye ya IV ya 15 mg / kg (n = 3) cyangwa 10 mg / kg (n = 45) cyangwa ku rundi rwego rwose binyuze mu nzira ya IV, IP, na PO.

Ububiko

Imiterere yimiti

Bifitanye isano na Biologiya

Bifitanye isano na Biologiya