Ibisobanuro

Hydrochlorothiazide (HCTZ), imiti ikoreshwa mu kanwa ya diuretique yo mu cyiciro cya thiazide, ibuza guhindura TGF-β/ Inzira yerekana ibimenyetso.Hydrochlorothiazide igira ingaruka zingirakamaro ziva mumitsi binyuze mu gufungura umuyoboro wa calcium ukora calcium (KCA).Hydrochlorothiazide itezimbere imikorere yumutima, igabanya fibrosis kandi igira ingaruka mbi.

Amavu n'amavuko

Hydrochlorothiazide numuti wa diuretic wo murwego rwa thiazide.

Muri Vitro

Hydrochlorothiazide ni murwego rwa thiazide ya diuretics.Igabanya umuvuduko wamaraso ikora kumpyiko kugirango igabanye sodium (Na) reabsorption muri tubule ya kure.Urubuga runini rwibikorwa muri nephron rugaragara kuri electroneutral Na + -Cl bafatanya gutwara bahatanira urubuga rwa chloride kubatwara.Kubangamira ubwikorezi bwa Na muri tubule ya kure, hydrochlorothiazide itera natriuresis hamwe no gutakaza amazi.Thiazide yongera reabsorption ya calcium muriki gice muburyo butajyanye no gutwara sodium.Byongeye kandi, hamwe nubundi buryo, Hydrochlorothiazide yizera ko igabanya ubukana bwamaraso.

Hydrochlorothiazide (HCTZ; bygavage mu kanwa; 12,5 mg / kg / d; ibyumweru 8) yatezimbere imikorere yumutima, igabanya fibrosis yumutima hamwe nigice cya kolagen, kugabanya imvugo ya AT1, TGF-β na Smad2 mumitima yumutima mubantu bakuze Sprague Dawley imbeba.Mubyongeyeho, hydrochlorothiazide igabanya plasma angiotensin II na aldosterone.Byongeye kandi, hydrochlorothiazide ibuza angiotensin II-iterwa na TGF-β1 na Smad2 imvugo ya proteyine muri fibroblast ya neonatal imbeba.

Imiterere yimiti