Ibisobanuro

Hydrochlorothiazide (HCTZ), imiti ikoreshwa mu kanwa yo mu bwoko bwa thiazide, ibuza guhindura TGF-β/ Inzira yerekana ibimenyetso. Hydrochlorothiazide igira ingaruka zitaziguye zifata imitsi binyuze mu gufungura umuyoboro wa calcium ukoreshwa na calcium (KCA). Hydrochlorothiazide itezimbere imikorere yumutima, igabanya fibrosis kandi igira ingaruka mbi.

Amavu n'amavuko

Hydrochlorothiazide numuti wa diuretique wo murwego rwa thiazide.

Muri Vitro

Hydrochlorothiazide ni mubyiciro bya thiazide ya diuretics. Igabanya umuvuduko wamaraso ikora kumpyiko kugirango igabanye sodium (Na) reabsorption muri tubule ya kure. Ikibanza kinini cyibikorwa muri nephron kigaragara kuri electroneutral Na + -Cl bafatanya gutwara bahatanira urubuga rwa chloride kubatwara. Kubangamira ubwikorezi bwa Na muri tubule ya kure, hydrochlorothiazide itera natriuresis hamwe no gutakaza amazi hamwe. Thiazide yongera reabsorption ya calcium muri iki gice muburyo butajyanye no gutwara sodium. Byongeye kandi, hamwe nubundi buryo, Hydrochlorothiazide yizera ko igabanya ubukana bwamaraso.

Hydrochlorothiazide (HCTZ; bygavage mu kanwa; 12,5 mg / kg / d; ibyumweru 8) yateje imbere imikorere yumutima, igabanya fibrosis yumutima hamwe nigice cya kolagen, kugabanuka kwa AT1, TGF-β na Smad2 mumyanya yumutima mubantu bakuze Sprague Dawley imbeba. Byongeye kandi, hydrochlorothiazide igabanya plasma angiotensin II na aldosterone. Byongeye kandi, hydrochlorothiazide ibuza angiotensin II iterwa na TGF-β1 na Smad2 ya protein imvugo muri neonatal imbeba ya ventrobular fibroblast.

Imiterere yimiti