Daclatasvir Dihydrochloride
Ibisobanuro
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) ni imbaraga kandi ikora mumanwaPoroteyine ya HCV NS5Ainhibitor hamweEC50s Urutonde rwa 9-146 pM kurigenotypes nyinshi za HCV.Daclatasvir dihydrochloride nayo ni aanion organic itwara polypeptide 1B (OATP1B)naOATP1B3inhibitor hamweIC50s ya 1.5 µM na 3.27 µM.
IC50& Intego
EC50: 50 pM (genotype ya HCV 1a), 9 pM (genotype ya HCV ya 1b), 71 pM HCV ikoporora genotype 5a)[1]
Kd: 8 nM (NS5A33-202) na 210 nM (NS5A26-202)[2]
IC50: 1.5 µM (OATP1B) na 3.27 µM (OATP1B3)[3]
Muri Vitro
Daclatasvir (BMS-790052) yerekana ibikorwa bikomeye byo kubuza genotypes zose zapimwe, hamwe na EC50indangagaciro kuva kuri 9 pM kugeza 146 pM.Daclatasvir ibuza genotype ya HCV 1a, 1b, 2a, 3a, 4a na 5a hamwe na EC50indangagaciro za 50 pM, 9 pM, 71 pM, 146 pM, 12 pM na 33 pM.Daclatasvir ninzitizi ikomeye ya JFH-1 genotype 2a virusi yandura yigana mumico ya selile (EC50= 28 pM)[1].Daclatasvir (BMS-790052) ihuza cyane na NS5A33-202 na NS5A26-202 hamwe na Kds ya 8 nM na 210 nM[2].
Ububiko
| Ifu | -20 ° C. | Imyaka 3 |
| 4 ° C. | Imyaka 2 | |
| Mubishobora | -80 ° C. | Amezi 6 |
| -20 ° C. | Ukwezi |
Ikigeragezo cya Clinical
| Umubare wa NCT | Umuterankunga | Imiterere | Itariki yo gutangiriraho | Icyiciro |
| NCT03369327 | Ishuri Rikuru ryubuvuzi rya Tehran | Uruganda rukora imiti ya RojanPharma | Indwara ya Hepatitis C Yanduye, Igisubizo cyo Kuvura | Virusi ya Immunodeficiency ya muntu | Ku ya 1 Mutarama 2017 | Icyiciro cya 3 |
| NCT03485846 | R-Pharm | Almedis | Indwara ya Hepatite idakira C Genotype 1b | Ku ya 27 Ugushyingo 2017 | Icyiciro cya 2 |
| NCT01016912 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2009 | Icyiciro cya 2 |
| NCT01629732 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Werurwe 2013 | Icyiciro cya 2 |
| NCT01497834 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mutarama 2012 | Icyiciro cya 3 |
| NCT01973049 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2013 | Icyiciro cya 3 |
| NCT00663208 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. | Gicurasi 2008 | Icyiciro cya 2 |
| NCT02576314 | Ikigo cyubushakashatsi bwubuzima nubuzima | Beijing 302 Ibitaro | Indwara ya Hepatite C idakira | Gicurasi 2015 | Icyiciro cya 3 |
| NCT02756936 | Ikigo Cyukuri Cyubushakashatsi, Misiri | Zeta Pharma Pharmaceutical Industries | Amagara mazima | Gashyantare 2016 | Icyiciro cya 1 |
| NCT02771405 | National Hepatology & Tropical Medicine Research Institute | Kaminuza ya Cairo | Indwara ya Hepatite C, karande | Kanseri ya Hepatocellular | Werurwe 2016 | Icyiciro cya 3 |
| NCT03706898 | Viriom | VIH-1-kwandura | Ubumuga bwo mu nda | Ku ya 1 Ukwakira 2018 | Icyiciro cya 1 |
| NCT02319031 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Gashyantare 2015 | Icyiciro cya 3 |
| NCT02124044 | Ikigo cyigihugu cyubuzima Clinical Centre (CC) | Ikigo cyigihugu gishinzwe allergie nindwara zanduza (NIAID) | Bristol-Myers Squibb | VIH-HCV | Gashyantare 2014 | Icyiciro cya 2 |
| NCT02551861 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2015 | Icyiciro cya 2 |
| NCT00859053 | Bristol-Myers Squibb | Indwara idahagije | Werurwe 2009 | Icyiciro cya 1 |
| NCT01257204 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Ukuboza 2010 | Icyiciro cya 2 |
| NCT03063879 | Ishuri Rikuru ry'Ubuvuzi rya Tehran | Ahvaz Jundishapur University of Science Science | Shiraz University of Science Science | Hamadan University of Medical Science | Indwara ya Hepatite C, idakira | Kunanirwa kw'impyiko zidakira | Ku ya 1 Mata 2017 | Icyiciro cya 4 |
| NCT01017575 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2009 | Icyiciro cya 2 |
| NCT02865369 | Sang Gyune Kim | Ibitaro bya kaminuza ya Seoul ya Boramae | Ibitaro bya Severance | Ibitaro bya kaminuza ya Inha | Kaminuza ya Koreya | Ibitaro by’ubuvuzi bya kaminuza ya Gachon | Ibitaro bya kaminuza ya Hanyang | Ibitaro bya Ewha Womans | | Indwara ya Hepatite idakira C. | Nzeri 2016 |
|
| NCT04070235 | Nanjing Sanhome Pharmaceutical, Co, Ltd. | Indwara ya Hepatite C, idakira | Ku ya 29 Werurwe 2019 | Icyiciro cya 2 | Icyiciro cya 3 |
| NCT03487848 | Bristol-Myers Squibb | Indwara ya Hepatite C | Indwara ya Hepatite idakira | Ku ya 18 Gicurasi 2018 | Icyiciro cya 2 |
| NCT00904059 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Gicurasi 2009 | Icyiciro cya 1 |
| NCT02107365 | Ikigo cy’igihugu cy’ubuzima n’ubushakashatsi mu Bufaransa-Ikigo cy’igihugu cy’Ubufaransa gishinzwe ubushakashatsi kuri sida na virusi ya Hepatite (Inserm-ANRS) | Bristol-Myers Squibb | Indwara ya Hepatite C Virusi Yanduye 4 | Ugushyingo 2013 | Icyiciro cya 2 |
| NCT02397395 | Janssen R&D Irlande | Kutagira Impyiko | Indwara yanyuma-Indwara | Gicurasi 2015 | Icyiciro cya 2 |
| NCT03169348 | Kaminuza ya Assiut | Indwara ya Hepatite C. | Ku ya 1 Ugushyingo 2017 | Ntabwo ari ngombwa |
| NCT02323594 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2014 | Icyiciro cya 1 |
| NCT03537196 | Ikigo cy’igihugu cy’ubuzima n’ubushakashatsi mu Bufaransa-Ikigo cy’igihugu cy’Ubufaransa gishinzwe ubushakashatsi kuri SIDA na Hepatite ya virusi (Inserm-ANRS) | Indwara ya Hepatite C | Gukoresha ibiyobyabwenge | Indwara ya Hepatite C. | Ku ya 13 Ugushyingo 2018 | Icyiciro cya 4 |
| NCT02103569 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mata 2014 | Icyiciro cya 1 |
| NCT02772744 | Kaminuza ya Zagazig | Kaminuza ya Cairo | Indwara ya Hepatite C. | Ku ya 1 Ugushyingo 2017 |
|
| NCT01718158 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mutarama 2013 | Icyiciro cya 3 |
| NCT02496078 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Kanama 2015 | Icyiciro cya 3 |
| NCT01425970 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Gicurasi 2012 | Icyiciro cya 2 |
| NCT01471574 | Bristol-Myers Squibb | Indwara ya Hepatite C, Ubwoko bwa 1 | Ukuboza 2011 | Icyiciro cya 3 |
| NCT01573351 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Gicurasi 2012 | Icyiciro cya 3 |
| NCT01938625 | Janssen R&D Irlande | Indwara ya Hepatite C, idakira | Ku ya 12 Ukuboza 2013 | Icyiciro cya 2 |
| NCT01492426 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mutarama 2012 | Icyiciro cya 3 |
| NCT03480932 | Johns Hopkins Bloomberg Ishuri ryubuzima rusange | Ikigo cyigihugu gishinzwe kurwanya ibiyobyabwenge (NIDA) | Ikigo cya YR Gaitonde gishinzwe ubushakashatsi nuburezi kuri sida | Indwara ya Hepatite C, idakira | Ku ya 2 Gashyantare 2018 | Icyiciro cya 2 | Icyiciro cya 3 |
| NCT03163849 | Kaminuza ya Assiut | Indwara ya Hepatite idakira c | Ku ya 1 Nzeri 2019 | Icyiciro cya 3 |
| NCT01581203 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Gicurasi 2012 | Icyiciro cya 3 |
| NCT01492504 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ku ya 7 Gashyantare 2012 |
|
| NCT03686722 | Mohamed Raslan | Ain Shams University | Ikigo cy’ubushakashatsi ku biyobyabwenge, Cairo, Misiri | Indwara ya Diyabete, Ubwoko bwa 2 | Indwara ya Hepatite C | Imiti | Ku ya 9 Nzeri 2017 | Icyiciro cya 1 |
| NCT02262728 | Janssen Ubushakashatsi & Iterambere, LLC | Indwara ya Hepatite C, idakira | Ku ya 30 Nzeri 2014 | Icyiciro cya 2 |
| NCT02349048 | Janssen Ubushakashatsi & Iterambere, LLC | Virusi ya Hepatite C. | Mutarama 2015 | Icyiciro cya 2 |
| NCT03882307 | Kaminuza ya Assiut | Indwara ya Hepatite C, idakira | Gicurasi 2020 | Icyiciro cya mbere |
| NCT02758509 | Parc de Salut Mar | Indwara ya Hepatite idakira C | Cirrhose | Ku ya 1 Mutarama 2010 |
|
| NCT01795911 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Werurwe 2013 | Icyiciro cya 2 |
| NCT03549832 | Kaminuza ya Assiut | Kaminuza ya Sohag | Kaminuza yo mu majyepfo | Guhuza HCV | Ku ya 1 Mutarama 2018 | Ntabwo ari ngombwa |
| NCT02161939 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. |
| |
| NCT01309932 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Werurwe 2011 | Icyiciro cya 2 |
| NCT01995266 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ku ya 28 Gashyantare 2014 | Icyiciro cya 3 |
| NCT02640157 | AbbVie | Indwara ya Hepatite idakira C | Virusi ya Hepatite C | Genotype ya 3 Hepatite C. | Ukuboza 2015 | Icyiciro cya 3 |
| NCT02032875 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Werurwe 2014 | Icyiciro cya 3 |
| NCT02624063 | Kaminuza nkuru ya São Paulo | Indwara ya Hepatite C, idakira | Ukuboza 2015 | Icyiciro cya 4 |
| NCT00546715 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. | Ugushyingo 2007 | Icyiciro cya 1 | Icyiciro cya 2 |
| NCT01718145 | Bristol-Myers Squibb | Indwara ya Hepatite C Yanduye | Ugushyingo 2012 | Icyiciro cya 3 |
| NCT01616524 | Bristol-Myers Squibb | Virusi ya Hepatite C (HCV) | Nyakanga 2012 | Icyiciro cya 3 |
| NCT02032901 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mutarama 2014 | Icyiciro cya 3 |
| NCT03540212 | Kaminuza ya Ain Shams | Indwara idakira ya HCV | Ku ya 10 Ukuboza 2017 | Icyiciro cya 2 | Icyiciro cya 3 |
| NCT02097966 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. |
| |
| NCT02596880 | Ishuri Rikuru ry'Ubuvuzi rya Tehran | Indwara ya Hepatite C | Cirrhose | Nzeri 2015 | Icyiciro cya 3 |
| NCT04019717 | Atea Pharmaceuticals, Inc. | Indwara ya Hepatite C | Indwara ya Hepatite C, idakira | Indwara ya Hepatite idakira C | Indwara ya Hepatite C | Indwara ya HCV | Ku ya 20 Kamena 2019 | Icyiciro cya 2 |
| NCT02992457 | Kaminuza ya Tanta | Indwara ya Hepatite C. | Mutarama 2015 | Icyiciro cya 4 |
| NCT03547895 | Kaminuza ya Zagazig | Indwara ya Cirrhose | Ku ya 1 Kamena 2015 | Ntabwo ari ngombwa |
| NCT03004625 | Ibitaro by’Urwibutso rwa Kaohsiung Chung-Ho | Ibitaro by’Urwibutso rwa Chang Gung | Ibitaro bya Kaminuza bya Tayiwani | Ibitaro Bikuru by’abasirikare ba Taipei, Tayiwani | Ibitaro bya Kaminuza by’ubuvuzi mu Bushinwa | Ibitaro bya Kaminuza bya Cheng-Kung | Indwara ya Hepatite C. | Ugushyingo 2016 | Icyiciro cya 3 |
| NCT01051414 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mata 2010 | Icyiciro cya 2 |
| NCT02309450 | Ikigo cy’igihugu cy’ubuzima n’ubushakashatsi mu Bufaransa-Ikigo cy’igihugu cy’Ubufaransa gishinzwe ubushakashatsi kuri sida na virusi ya Hepatite (Inserm-ANRS) | Bristol-Myers Squibb | Indwara ya Hepatite C Virusi Yanduye 4 | Ukuboza 2014 | Icyiciro cya 2 |
| NCT01628692 | Bristol-Myers Squibb | Janssen Ubushakashatsi & Iterambere, LLC | Virusi ya Hepatite C. | Nyakanga 2012 | Icyiciro cya 2 |
| NCT03186313 | Ibitaro byumwijima byo muri Egiputa | Ibitaro bya Wadi El Nil | Indwara ya Hepatite C. | Nzeri 2016 | Icyiciro cya 3 |
| NCT03063723 | Ibitaro bya gatatu bishamikiyeho, Sun Yat-Sen University | Indwara ya Hepatite idakira C (Disorder) | Ku ya 1 Mutarama 2016 |
|
| NCT00983957 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. | Ukwakira 2009 | Icyiciro cya 1 |
| NCT01725542 | Ikigo cy’igihugu cy’ubuzima n’ubushakashatsi mu Bufaransa-Ikigo cy’igihugu cy’Ubufaransa gishinzwe ubushakashatsi kuri sida na virusi ya Hepatite (Inserm-ANRS) | Bristol-Myers Squibb | Kwandura HCV-VIH | Ukuboza 2012 | Icyiciro cya 2 |
| NCT02282709 | Urufatiro rwubushakashatsi bwumwijima | Indwara ya Hepatite idakira C. | Gashyantare 2014 | Icyiciro cya 3 |
| NCT02032888 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Gashyantare 2014 | Icyiciro cya 3 |
| NCT03247296 | Kaminuza ya MTI | Indwara ya Hepatite C. | Ku ya 28 Gashyantare 2017 |
|
| NCT01389323 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Nzeri 2011 | Icyiciro cya 3 |
| NCT02556086 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2015 | Icyiciro cya 2 |
| NCT01741545 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Ku ya 31 Werurwe 2013 | Icyiciro cya 3 |
| NCT01866930 | Bristol-Myers Squibb | Indwara ya Hepatite C idakira | Ku ya 11 Nyakanga 2013 | Icyiciro cya 3 |
| NCT02268864 | Janssen-Cilag Mpuzamahanga NV | Indwara ya Hepatite C, idakira | Mutarama 2015 | Icyiciro cya 2 |
| NCT01797848 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Kamena 2014 | Icyiciro cya 3 |
| NCT03166280 | Eman Sayed Hassan Abd Allah | Kaminuza ya Assiut | Indwara ya Hepatite C. | Kamena 2017 |
|
| NCT02159352 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Kamena 2014 | Icyiciro cya 1 |
| NCT01125189 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Nyakanga 2010 | Icyiciro cya 2 |
| NCT03748745 | Nanjing Sanhome Pharmaceutical, Co, Ltd. | Imikoreshereze yibiyobyabwenge | Ku ya 19 Ugushyingo 2018 | Icyiciro cya 1 |
| NCT01012895 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. | Ukuboza 2009 | Icyiciro cya 2 |
| NCT02565888 | Kaminuza ya Radboud | Indwara ya Hepatite C | VIH | Ugushyingo 2015 | Icyiciro cya 1 |
| NCT02555943 | Ikigo cyubushakashatsi bwubuzima nubuzima | Beijing 302 Ibitaro | Ibitaro bya Nanfang bya kaminuza yubuvuzi bwamajyepfo | Indwara ya Hepatite C idakira | Guhuza HBV | Hepatite B Reactivation | Gashyantare 2015 | Icyiciro cya 2 | Icyiciro cya 3 |
| NCT02304159 | Tarek I. Hassanein, MD, FACP, FAG, AGAF | Ikigo cy’ubushakashatsi cya Californiya | Indwara ya Hepatite C | Cirrhose | Mutarama 2015 | Icyiciro cya 4 |
| NCT02580474 | Indirimbo ya Myeong Jun | Bristol-Myers Squibb | Ibitaro bya Kaminuza ya Soonchunhyang | Dankook | Ibitaro bya Kaminuza bya Chungnam | Ibitaro bya Koniang | Ibitaro bya Kaminuza bya Eulji | , Koreya | Ibitaro bya Severance | Ibitaro bya Kaminuza bya Koreya | Ibitaro Bikuru bya Eulji | Kaminuza Gatolika ya Koreya | Indwara ya Hepatite C. | Gashyantare 2016 | Icyiciro cya 4 |
| NCT02104843 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mata 2014 | Icyiciro cya 1 |
| NCT01428063 | Bristol-Myers Squibb | Indwara ya Hepatite C Yanduye | Nzeri 2011 | Icyiciro cya 2 |
| NCT02123654 | Bristol-Myers Squibb | Indwara ya Hepatite C Yanduye | Mata 2014 | Icyiciro cya 3 |
| NCT02565862 | Kaminuza ya Radboud | Indwara ya Hepatite C | Indwara ya Diyabete | Kurwanya insuline | Mutarama 2016 | Icyiciro cya 1 |
| NCT04211844 | Kaminuza ya Ain Shams | Indwara ya Hepatite idakira C. | Ku ya 1 Ukwakira 2019 |
|
| NCT00874770 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Kamena 2009 | Icyiciro cya 2 |
| NCT03883698 | Ishuri Rikuru ry'Ubuvuzi rya Sanjay Gandhi | Kunanirwa kw'impyiko, karande | Hepatite C. | Ku ya 15 Werurwe 2019 | Icyiciro cya 3 |
| NCT01448044 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2011 | Icyiciro cya 3 |
| NCT01359644 | Bristol-Myers Squibb | Pharmasset | Indwara ya Hepatite idakira C. | Kamena 2011 | Icyiciro cya 2 |
| NCT01842451 | Imiti ya Vertex Yashizwemo | Indwara ya Hepatite idakira C | CHC | HCV | Indwara ya Hepatite C. | Kamena 2013 | Icyiciro cya 2 |
| NCT02762448 | Ibitaro bya Komine ya Tainan | Indwara ya Hepatite c | Nyakanga 2016 |
|
| NCT02473211 | Ikigo cyubushakashatsi bwubuzima nubuzima | Beijing 302 Ibitaro | Indwara ya Hepatite C idakira | Mutarama 2015 | Icyiciro cya 2 | Icyiciro cya 3 |
| NCT01455090 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. | Ku ya 30 Ugushyingo 2011 | Icyiciro cya 2 |
| NCT03490097 | Kaminuza ya Ain Shams | Indwara ya Hepatite idakira c | Indwara ya Metabolic | Ku ya 1 Ukuboza 2017 | Icyiciro cya 2 | Icyiciro cya 3 |
| NCT01170962 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Kanama 2010 | Icyiciro cya 2 |
| NCT02333292 | Ibitaro bya Kaminuza bya Valme | Ibitaro del SAS de Jerez | Ibitaro Bikuru bya Universitario Elche | Ibitaro La Línea de la Concepción | Complexo Hospitalario Universitario de A Coruña | Ibitaro bya Figueres | Ibitaro Universitario Puerto Real | Ibitaro Universitario Virgen de la Victoria | Ibitaro Universitario de Canarias | Ibitaro Bikuru bya Universitario de Alicante | Ibitaro Universitario Araba | Ibitaro Royo Vilanova | Ibitaro Universitario de Burgos | Complejo Hospitalario Universitario de Huelva | Ibitaro Universitario Reina Sofia de Cordoba | Ibitaro Universitario Virgen Macarena | Complexo Hospitalario Universitario de Vigo | Clinica Universidad de Navigo | Navarra | Ibitaro Clinico Universitario San Cecilio | Ibitaro Universitario La Fe | Ibitaro Bikuru Universitario de Valencia | Ibitaro Universitario Infanta Leonor | Ibitaro Universitario de Gran Canaria | Ibitaro Bikuru bya Universitario Santa Lucía | Centro Penitenciario Alicante 1 | Ibitaro bya Universitario Carlos Haya | la L.uz | Ibitaro Bikuru bya Universitario de Castellón | Ibitaro Parc Taulí, Sabadell | Indwara ya Hepatite C idakira | Ukuboza 2014 |
|
| NCT03200184 | Ishuri Rikuru ry'Ubuvuzi rya Tehran | Indwara ya Hepatite C. | Ku ya 1 Nzeri 2016 | Icyiciro cya 4 |
| NCT03188276 | Ibitaro bya gatatu bishamikiyeho, Sun Yat-Sen University | Indwara ya Hepatite idakira C. | Ku ya 1 Gashyantare 2016 | Icyiciro cya mbere |
| NCT01830205 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Nzeri 2012 | Icyiciro cya 1 |
Icyifuzo18Imishinga yo gusuzuma ireme ryemejwe4, na6imishinga iremezwa.
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