Daclatasvir Dihydrochloride
Ibisobanuro
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) ni imbaraga kandi ikora mu kanwaPoroteyine ya HCV NS5Ainhibitor hamweEC50s Urutonde rwa 9-146 pM kurigenotypes nyinshi za HCV. Daclatasvir dihydrochloride nayo ni aanion organic itwara polypeptide 1B (OATP1B)naOATP1B3inhibitor hamweIC50s ya 1.5 µM na 3.27 µM, uko bikurikirana.
IC50& Intego
EC50: 50 pM (genotype ya HCV 1a), 9 pM (genotype ya HCV ya 1b), 71 pM HCV ikoporora genotype 5a)[1]
Kd: 8 nM (NS5A33-202) na 210 nM (NS5A26-202)[2]
IC50: 1.5 µM (OATP1B) na 3.27 µM (OATP1B3)[3]
Muri Vitro
Daclatasvir (BMS-790052) yerekana ibikorwa bikomeye byo kubuza genotypes zose zapimwe, hamwe na EC50indangagaciro kuva kuri 9 pM kugeza 146 pM. Daclatasvir ibuza HCV replicon genotype 1a, 1b, 2a, 3a, 4a na 5a hamwe na EC50indangagaciro za 50 pM, 9 pM, 71 pM, 146 pM, 12 pM na 33 pM. Daclatasvir ni inzitizi ikomeye ya virusi ya JFH-1 genotype 2a yandura mu muco w'akagari (EC50= 28 pM)[1]. Daclatasvir (BMS-790052) ihuza cyane na NS5A33-202 na NS5A26-202 hamwe na Kds ya 8 nM na 210 nM[2].
Ububiko
Ifu | -20 ° C. | Imyaka 3 |
4 ° C. | Imyaka 2 | |
Mubishobora | -80 ° C. | Amezi 6 |
-20 ° C. | Ukwezi 1 |
Ikigeragezo cya Clinical
Umubare wa NCT | Umuterankunga | Imiterere | Itariki yo gutangiriraho | Icyiciro |
NCT03369327 | Ishuri Rikuru ry'Ubuvuzi rya Tehran | Uruganda rukora imiti rwa RojanPharma | Indwara ya Hepatitis C Yanduye, Igisubizo cyo Kuvura | Virusi ya Immunodeficiency ya muntu | Ku ya 1 Mutarama 2017 | Icyiciro cya 3 |
NCT03485846 | R-Pharm | Almedis | Indwara ya Hepatite idakira C Genotype 1b | Ku ya 27 Ugushyingo 2017 | Icyiciro cya 2 |
NCT01016912 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2009 | Icyiciro cya 2 |
NCT01629732 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Werurwe 2013 | Icyiciro cya 2 |
NCT01497834 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mutarama 2012 | Icyiciro cya 3 |
NCT01973049 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2013 | Icyiciro cya 3 |
NCT00663208 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. | Gicurasi 2008 | Icyiciro cya 2 |
NCT02576314 | Ikigo cyubushakashatsi bwubuzima nubuzima | Beijing 302 Ibitaro | Indwara ya Hepatite idakira C. | Gicurasi 2015 | Icyiciro cya 3 |
NCT02756936 | Ikigo Cyukuri Cyubushakashatsi, Misiri | Zeta Pharma Pharmaceutical Industries | Amagara mazima | Gashyantare 2016 | Icyiciro cya 1 |
NCT02771405 | Ikigo cy'igihugu gishinzwe ubuvuzi bwa Hepatologiya & Tropical Medicine Research Institute | Kaminuza ya Cairo | Indwara ya Hepatite C, karande | Indwara ya Hepatocellular Carcinoma | Werurwe 2016 | Icyiciro cya 3 |
NCT03706898 | Viriom | VIH-1-kwandura | Ubumuga bwo mu nda | Ku ya 1 Ukwakira 2018 | Icyiciro cya 1 |
NCT02319031 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Gashyantare 2015 | Icyiciro cya 3 |
NCT02124044 | Ikigo cyigihugu cyubuzima Clinical Centre (CC) | Ikigo cyigihugu gishinzwe allergie nindwara zanduza (NIAID) | Bristol-Myers Squibb | VIH-HCV | Gashyantare 2014 | Icyiciro cya 2 |
NCT02551861 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2015 | Icyiciro cya 2 |
NCT00859053 | Bristol-Myers Squibb | Indwara idahagije | Werurwe 2009 | Icyiciro cya 1 |
NCT01257204 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Ukuboza 2010 | Icyiciro cya 2 |
NCT03063879 | Ishuri Rikuru ry’Ubuvuzi rya Tehran | Ahvaz Jundishapur Kaminuza y’Ubuvuzi | Shiraz University of Science Science | Kaminuza y’ubuvuzi ya Hamadan | Indwara ya Hepatite C, idakira | Kunanirwa kw'impyiko zidakira | Ku ya 1 Mata 2017 | Icyiciro cya 4 |
NCT01017575 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2009 | Icyiciro cya 2 |
NCT02865369 | Sang Gyune Kim | Ibitaro bya Boramae bya kaminuza nkuru ya Seoul | Ibitaro bya Severance | Ibitaro bya kaminuza ya Inha | Kaminuza ya Koreya | Ikigo cy’ubuvuzi cya kaminuza ya Gachon | Ibitaro bya kaminuza ya Hanyang | Ibitaro bya kaminuza bya Ewha Womans | Ibitaro bya Mokdong | | Indwara ya Hepatite idakira C. | Nzeri 2016 |
|
NCT04070235 | Nanjing Sanhome Pharmaceutical, Co, Ltd. | Indwara ya Hepatite C, karande | Ku ya 29 Werurwe 2019 | Icyiciro cya 2 | Icyiciro cya 3 |
NCT03487848 | Bristol-Myers Squibb | Indwara ya Hepatite C | Indwara idakira | Ku ya 18 Gicurasi 2018 | Icyiciro cya 2 |
NCT00904059 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Gicurasi 2009 | Icyiciro cya 1 |
NCT02107365 | Ikigo cy’igihugu cy’Ubufaransa gishinzwe Ubushakashatsi n’Ubuvuzi-Ikigo cy’igihugu cy’Ubufaransa gishinzwe ubushakashatsi kuri SIDA na Hepatite ya virusi (Inserm-ANRS) | Bristol-Myers Squibb | Hepatitis C Virusi Genotype 4 Kwandura | Ugushyingo 2013 | Icyiciro cya 2 |
NCT02397395 | Janssen R&D Irlande | Impyiko Zimpyiko | Indwara yanyuma-Indwara Yimpyiko | Gicurasi 2015 | Icyiciro cya 2 |
NCT03169348 | Kaminuza ya Assiut | Indwara ya Hepatite C. | Ku ya 1 Ugushyingo 2017 | Ntabwo ari ngombwa |
NCT02323594 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2014 | Icyiciro cya 1 |
NCT03537196 | Ikigo cy’igihugu cy’Ubufaransa gishinzwe Ubushakashatsi n’Ubuvuzi-Ikigo cy’igihugu cy’Ubufaransa gishinzwe ubushakashatsi kuri SIDA na Hepatite ya virusi (Inserm-ANRS) | Indwara ya Hepatite C | Gukoresha ibiyobyabwenge | Indwara ya Hepatite C. | Ku ya 13 Ugushyingo 2018 | Icyiciro cya 4 |
NCT02103569 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mata 2014 | Icyiciro cya 1 |
NCT02772744 | Kaminuza ya Zagazig | Kaminuza ya Cairo | Indwara ya Hepatite C. | Ku ya 1 Ugushyingo 2017 |
|
NCT01718158 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mutarama 2013 | Icyiciro cya 3 |
NCT02496078 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Kanama 2015 | Icyiciro cya 3 |
NCT01425970 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Gicurasi 2012 | Icyiciro cya 2 |
NCT01471574 | Bristol-Myers Squibb | Indwara ya Hepatite C, Genotype 1 | Ukuboza 2011 | Icyiciro cya 3 |
NCT01573351 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Gicurasi 2012 | Icyiciro cya 3 |
NCT01938625 | Janssen R&D Irlande | Indwara ya Hepatite C, karande | Ku ya 12 Ukuboza 2013 | Icyiciro cya 2 |
NCT01492426 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mutarama 2012 | Icyiciro cya 3 |
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NCT01581203 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Gicurasi 2012 | Icyiciro cya 3 |
NCT01492504 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ku ya 7 Gashyantare 2012 |
|
NCT03686722 | Mohamed Raslan | Ain Shams University | Ikigo cy’ubushakashatsi ku biyobyabwenge, Cairo, Misiri | Indwara ya Diyabete, Ubwoko bwa 2 | Hepatite C | Imiti | Ku ya 9 Nzeri 2017 | Icyiciro cya 1 |
NCT02262728 | Janssen Ubushakashatsi & Iterambere, LLC | Indwara ya Hepatite C, karande | Ku ya 30 Nzeri 2014 | Icyiciro cya 2 |
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NCT03882307 | Kaminuza ya Assiut | Indwara ya Hepatite C, karande | Gicurasi 2020 | Icyiciro cya mbere |
NCT02758509 | Parc de Salut Mar. | Indwara ya Hepatite idakira C | Cirrhose | Ku ya 1 Mutarama 2010 |
|
NCT01795911 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Werurwe 2013 | Icyiciro cya 2 |
NCT03549832 | Kaminuza ya Assiut | Kaminuza ya Sohag | Kaminuza yo mu majyepfo | HCV | Ku ya 1 Mutarama 2018 | Ntabwo ari ngombwa |
NCT02161939 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. |
| |
NCT01309932 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Werurwe 2011 | Icyiciro cya 2 |
NCT01995266 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ku ya 28 Gashyantare 2014 | Icyiciro cya 3 |
NCT02640157 | AbbVie | Indwara ya Hepatite idakira C | Virusi ya Hepatite C | Genotype ya 3 Hepatite C. | Ukuboza 2015 | Icyiciro cya 3 |
NCT02032875 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Werurwe 2014 | Icyiciro cya 3 |
NCT02624063 | Kaminuza nkuru ya São Paulo | Indwara ya Hepatite C, karande | Ukuboza 2015 | Icyiciro cya 4 |
NCT00546715 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. | Ugushyingo 2007 | Icyiciro cya 1 | Icyiciro cya 2 |
NCT01718145 | Bristol-Myers Squibb | Indwara ya Hepatite C Yanduye | Ugushyingo 2012 | Icyiciro cya 3 |
NCT01616524 | Bristol-Myers Squibb | Virusi ya Hepatite C (HCV) | Nyakanga 2012 | Icyiciro cya 3 |
NCT02032901 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mutarama 2014 | Icyiciro cya 3 |
NCT03540212 | Kaminuza ya Ain Shams | Indwara idakira ya HCV | Ku ya 10 Ukuboza 2017 | Icyiciro cya 2 | Icyiciro cya 3 |
NCT02097966 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. |
| |
NCT02596880 | Ishuri Rikuru ry'Ubuvuzi rya Tehran | Indwara ya Hepatite C | Cirrhose | Nzeri 2015 | Icyiciro cya 3 |
NCT04019717 | Atea Pharmaceuticals, Inc. | Indwara ya Hepatite C | Indwara ya Hepatite C, idakira | Indwara ya Hepatite idakira C | Indwara ya Hepatite C | Indwara ya HCV | Ku ya 20 Kamena 2019 | Icyiciro cya 2 |
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NCT03547895 | Kaminuza ya Zagazig | Indwara ya Cirrhose | Ku ya 1 Kamena 2015 | Ntabwo ari ngombwa |
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NCT01051414 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mata 2010 | Icyiciro cya 2 |
NCT02309450 | Ikigo cy’igihugu cy’Ubufaransa gishinzwe Ubushakashatsi n’Ubuvuzi-Ikigo cy’igihugu cy’Ubufaransa gishinzwe ubushakashatsi kuri SIDA na Hepatite ya virusi (Inserm-ANRS) | Bristol-Myers Squibb | Hepatitis C Virusi Genotype 4 Kwandura | Ukuboza 2014 | Icyiciro cya 2 |
NCT01628692 | Bristol-Myers Squibb | Janssen Ubushakashatsi & Iterambere, LLC | Virusi ya Hepatite C. | Nyakanga 2012 | Icyiciro cya 2 |
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NCT03063723 | Ibitaro bya gatatu bishamikiye kuri kaminuza, Sun Yat-Sen | Indwara ya Hepatite idakira C (Disorder) | Ku ya 1 Mutarama 2016 |
|
NCT00983957 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. | Ukwakira 2009 | Icyiciro cya 1 |
NCT01725542 | Ikigo cy’igihugu cy’Ubufaransa gishinzwe Ubushakashatsi n’Ubuvuzi-Ikigo cy’igihugu cy’Ubufaransa gishinzwe ubushakashatsi kuri SIDA na Hepatite ya virusi (Inserm-ANRS) | Bristol-Myers Squibb | Kwandura HCV-VIH | Ukuboza 2012 | Icyiciro cya 2 |
NCT02282709 | Urufatiro rwubushakashatsi bwumwijima | Indwara ya Hepatite idakira C. | Gashyantare 2014 | Icyiciro cya 3 |
NCT02032888 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Gashyantare 2014 | Icyiciro cya 3 |
NCT03247296 | Kaminuza ya MTI | Indwara ya Hepatite C. | Ku ya 28 Gashyantare 2017 |
|
NCT01389323 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Nzeri 2011 | Icyiciro cya 3 |
NCT02556086 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2015 | Icyiciro cya 2 |
NCT01741545 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Ku ya 31 Werurwe 2013 | Icyiciro cya 3 |
NCT01866930 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. | Ku ya 11 Nyakanga 2013 | Icyiciro cya 3 |
NCT02268864 | Janssen-Cilag Mpuzamahanga NV | Indwara ya Hepatite C, karande | Mutarama 2015 | Icyiciro cya 2 |
NCT01797848 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Kamena 2014 | Icyiciro cya 3 |
NCT03166280 | Eman Sayed Hassan Abd Allah | Kaminuza ya Assiut | Indwara ya Hepatite C. | Kamena 2017 |
|
NCT02159352 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Kamena 2014 | Icyiciro cya 1 |
NCT01125189 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Nyakanga 2010 | Icyiciro cya 2 |
NCT03748745 | Nanjing Sanhome Pharmaceutical, Co, Ltd. | Imikoreshereze yibiyobyabwenge | Ku ya 19 Ugushyingo 2018 | Icyiciro cya 1 |
NCT01012895 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. | Ukuboza 2009 | Icyiciro cya 2 |
NCT02565888 | Kaminuza ya Radboud | Indwara ya Hepatite C | VIH | Ugushyingo 2015 | Icyiciro cya 1 |
NCT02555943 | Ikigo cyubushakashatsi bwubuzima nubuzima | Beijing 302 Ibitaro | Ibitaro bya Nanfang bya kaminuza yubuvuzi bwamajyepfo | Indwara ya Hepatite idakira C | HBV Coinfection | Hepatitis B Reactivation | Gashyantare 2015 | Icyiciro cya 2 | Icyiciro cya 3 |
NCT02304159 | Tarek I. Hassanein, MD, FACP, FAG, AGAF | Ikigo cy’ubushakashatsi cy’amajyepfo ya California | Indwara ya Hepatite C | Cirrhose | Mutarama 2015 | Icyiciro cya 4 |
NCT02580474 | Indirimbo ya Myeong Jun | Bristol-Myers Squibb | Ibitaro bya Kaminuza ya Soonchunhyang | Kaminuza ya Dankook | Ibitaro bya Kaminuza bya Chungnam | Ibitaro bya Koniang | Ibitaro bya Kaminuza bya Eulji | Ibitaro bya Saint Vincent´s, Koreya | Ibitaro bya Kaminuza bya Konkuk | Ibitaro bya Cheongju Mutagatifu Mary´s, Cheongju , Koreya | Ibitaro bya Severance | Ibitaro bya kaminuza ya Koreya ya Guro | Ibitaro Bikuru bya Eulji | Kaminuza Gatolika ya Koreya | Indwara ya Hepatite C. | Gashyantare 2016 | Icyiciro cya 4 |
NCT02104843 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mata 2014 | Icyiciro cya 1 |
NCT01428063 | Bristol-Myers Squibb | Indwara ya Hepatite C Yanduye | Nzeri 2011 | Icyiciro cya 2 |
NCT02123654 | Bristol-Myers Squibb | Indwara ya Hepatite C Yanduye | Mata 2014 | Icyiciro cya 3 |
NCT02565862 | Kaminuza ya Radboud | Hepatite C | Diyabete Mellitus | Kurwanya insuline | Mutarama 2016 | Icyiciro cya 1 |
NCT04211844 | Kaminuza ya Ain Shams | Indwara ya Hepatite idakira C. | Ku ya 1 Ukwakira 2019 |
|
NCT00874770 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Kamena 2009 | Icyiciro cya 2 |
NCT03883698 | Sanjay Gandhi Postgraduate Institute of Medical Science | Kunanirwa kw'impyiko, karande | Hepatite C. | Ku ya 15 Werurwe 2019 | Icyiciro cya 3 |
NCT01448044 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2011 | Icyiciro cya 3 |
NCT01359644 | Bristol-Myers Squibb | Pharmasset | Indwara ya Hepatite idakira C. | Kamena 2011 | Icyiciro cya 2 |
NCT01842451 | Imiti ya Vertex Yashizwemo | Indwara ya Hepatite idakira C | CHC | HCV | Indwara ya Hepatite C. | Kamena 2013 | Icyiciro cya 2 |
NCT02762448 | Ibitaro bya Komini ya Tainan | Indwara ya Hepatite c | Nyakanga 2016 |
|
NCT02473211 | Ikigo cyubushakashatsi bwubuzima nubuzima | Beijing 302 Ibitaro | Indwara ya Hepatite idakira C. | Mutarama 2015 | Icyiciro cya 2 | Icyiciro cya 3 |
NCT01455090 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. | Ku ya 30 Ugushyingo 2011 | Icyiciro cya 2 |
NCT03490097 | Kaminuza ya Ain Shams | Indwara ya Hepatite idakira c | Indwara ya Metabolic | Ku ya 1 Ukuboza 2017 | Icyiciro cya 2 | Icyiciro cya 3 |
NCT01170962 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Kanama 2010 | Icyiciro cya 2 |
NCT02333292 | Ibitaro bya Kaminuza bya Valme | Ibitaro del SAS de Jerez | Ibitaro Bikuru bya Universitario Elche | Ibitaro La Línea de la Concepción | Complexo Hospitalario Universitario de A Coruña | Ibitaro de Figueres | Ibitaro Universitario Puerto Real | Ibitaro Universitario Virgen de la Victoria | Ibitaro Universitario de Canarias | Ibitaro Bikuru Universitario de Alicante | Ibitaro Universitario Araba | Ibitaro Royo Vilanova | Ibitaro Universitario de Burgos | Complejo Hospitalario Universitario de Huelva | Ibitaro Universitario Reina Sofia de Cordoba | Ibitaro Universitario Virgen Macarena | Complexo Hospitalario Universitario de Vigo | Clinica Universidad de Navarra, Universidad de Navarra | Ibitaro Clinico Universitario San Cecilio | Universitario de Valencia | Ibitaro Universitario Infanta Leonor | Ibitaro Universitario de Gran Canaria | Ibitaro Bikuru Universitario Santa Lucía | Centro Penitenciario Alicante 1 | Ibitaro byo mu karere Universitario Carlos Haya | Ibitaro Virgen de la Luz | Ibitaro Bikuru bya Universitario de Castellón | Ibitaro Parc Taulí, Sabadell | Indwara ya Hepatite idakira C. | Ukuboza 2014 |
|
NCT03200184 | Ishuri Rikuru ry'Ubuvuzi rya Tehran | Indwara ya Hepatite C. | Ku ya 1 Nzeri 2016 | Icyiciro cya 4 |
NCT03188276 | Ibitaro bya gatatu bishamikiye kuri kaminuza, Sun Yat-Sen | Indwara ya Hepatite idakira C. | Ku ya 1 Gashyantare 2016 | Icyiciro cya mbere |
NCT01830205 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Nzeri 2012 | Icyiciro cya 1 |





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