Daclatasvir Dihydrochloride
Ibisobanuro
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) ni imbaraga kandi ikora mumanwaPoroteyine ya HCV NS5Ainhibitor hamweEC50s Urutonde rwa 9-146 pM kurigenotypes nyinshi za HCV.Daclatasvir dihydrochloride nayo ni aanion organic itwara polypeptide 1B (OATP1B)naOATP1B3inhibitor hamweIC50s ya 1.5 µM na 3.27 µM.
IC50& Intego
EC50: 50 pM (genotype ya HCV 1a), 9 pM (genotype ya HCV ya 1b), 71 pM HCV ikoporora genotype 5a)[1]
Kd: 8 nM (NS5A33-202) na 210 nM (NS5A26-202)[2]
IC50: 1.5 µM (OATP1B) na 3.27 µM (OATP1B3)[3]
Muri Vitro
Daclatasvir (BMS-790052) yerekana ibikorwa bikomeye byo kubuza genotypes zose zapimwe, hamwe na EC50indangagaciro kuva kuri 9 pM kugeza 146 pM.Daclatasvir ibuza genotype ya HCV 1a, 1b, 2a, 3a, 4a na 5a hamwe na EC50indangagaciro za 50 pM, 9 pM, 71 pM, 146 pM, 12 pM na 33 pM.Daclatasvir ninzitizi ikomeye ya JFH-1 genotype 2a virusi yandura yigana mumico ya selile (EC50= 28 pM)[1].Daclatasvir (BMS-790052) ihuza cyane na NS5A33-202 na NS5A26-202 hamwe na Kds ya 8 nM na 210 nM[2].
Ububiko
Ifu | -20 ° C. | Imyaka 3 |
4 ° C. | Imyaka 2 | |
Mubishobora | -80 ° C. | Amezi 6 |
-20 ° C. | Ukwezi |
Ikigeragezo cya Clinical
Umubare wa NCT | Umuterankunga | Imiterere | Itariki yo gutangiriraho | Icyiciro |
NCT03369327 | Ishuri Rikuru ryubuvuzi rya Tehran | Uruganda rukora imiti ya RojanPharma | Indwara ya Hepatitis C Yanduye, Igisubizo cyo Kuvura | Virusi ya Immunodeficiency ya muntu | Ku ya 1 Mutarama 2017 | Icyiciro cya 3 |
NCT03485846 | R-Pharm | Almedis | Indwara ya Hepatite idakira C Genotype 1b | Ku ya 27 Ugushyingo 2017 | Icyiciro cya 2 |
NCT01016912 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2009 | Icyiciro cya 2 |
NCT01629732 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Werurwe 2013 | Icyiciro cya 2 |
NCT01497834 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mutarama 2012 | Icyiciro cya 3 |
NCT01973049 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2013 | Icyiciro cya 3 |
NCT00663208 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. | Gicurasi 2008 | Icyiciro cya 2 |
NCT02576314 | Ikigo cyubushakashatsi bwubuzima nubuzima | Beijing 302 Ibitaro | Indwara ya Hepatite C idakira | Gicurasi 2015 | Icyiciro cya 3 |
NCT02756936 | Ikigo Cyukuri Cyubushakashatsi, Misiri | Zeta Pharma Pharmaceutical Industries | Amagara mazima | Gashyantare 2016 | Icyiciro cya 1 |
NCT02771405 | National Hepatology & Tropical Medicine Research Institute | Kaminuza ya Cairo | Indwara ya Hepatite C, karande | Kanseri ya Hepatocellular | Werurwe 2016 | Icyiciro cya 3 |
NCT03706898 | Viriom | VIH-1-kwandura | Ubumuga bwo mu nda | Ku ya 1 Ukwakira 2018 | Icyiciro cya 1 |
NCT02319031 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Gashyantare 2015 | Icyiciro cya 3 |
NCT02124044 | Ikigo cyigihugu cyubuzima Clinical Centre (CC) | Ikigo cyigihugu gishinzwe allergie nindwara zanduza (NIAID) | Bristol-Myers Squibb | VIH-HCV | Gashyantare 2014 | Icyiciro cya 2 |
NCT02551861 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2015 | Icyiciro cya 2 |
NCT00859053 | Bristol-Myers Squibb | Indwara idahagije | Werurwe 2009 | Icyiciro cya 1 |
NCT01257204 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Ukuboza 2010 | Icyiciro cya 2 |
NCT03063879 | Ishuri Rikuru ry'Ubuvuzi rya Tehran | Ahvaz Jundishapur University of Science Science | Shiraz University of Science Science | Hamadan University of Medical Science | Indwara ya Hepatite C, idakira | Kunanirwa kw'impyiko zidakira | Ku ya 1 Mata 2017 | Icyiciro cya 4 |
NCT01017575 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2009 | Icyiciro cya 2 |
NCT02865369 | Sang Gyune Kim | Ibitaro bya kaminuza ya Seoul ya Boramae | Ibitaro bya Severance | Ibitaro bya kaminuza ya Inha | Kaminuza ya Koreya | Ibitaro by’ubuvuzi bya kaminuza ya Gachon | Ibitaro bya kaminuza ya Hanyang | Ibitaro bya Ewha Womans | | Indwara ya Hepatite idakira C. | Nzeri 2016 |
|
NCT04070235 | Nanjing Sanhome Pharmaceutical, Co, Ltd. | Indwara ya Hepatite C, idakira | Ku ya 29 Werurwe 2019 | Icyiciro cya 2 | Icyiciro cya 3 |
NCT03487848 | Bristol-Myers Squibb | Indwara ya Hepatite C | Indwara ya Hepatite idakira | Ku ya 18 Gicurasi 2018 | Icyiciro cya 2 |
NCT00904059 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Gicurasi 2009 | Icyiciro cya 1 |
NCT02107365 | Ikigo cy’igihugu cy’ubuzima n’ubushakashatsi mu Bufaransa-Ikigo cy’igihugu cy’Ubufaransa gishinzwe ubushakashatsi kuri sida na virusi ya Hepatite (Inserm-ANRS) | Bristol-Myers Squibb | Indwara ya Hepatite C Virusi Yanduye 4 | Ugushyingo 2013 | Icyiciro cya 2 |
NCT02397395 | Janssen R&D Irlande | Kutagira Impyiko | Indwara yanyuma-Indwara | Gicurasi 2015 | Icyiciro cya 2 |
NCT03169348 | Kaminuza ya Assiut | Indwara ya Hepatite C. | Ku ya 1 Ugushyingo 2017 | Ntabwo ari ngombwa |
NCT02323594 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2014 | Icyiciro cya 1 |
NCT03537196 | Ikigo cy’igihugu cy’ubuzima n’ubushakashatsi mu Bufaransa-Ikigo cy’igihugu cy’Ubufaransa gishinzwe ubushakashatsi kuri SIDA na Hepatite ya virusi (Inserm-ANRS) | Indwara ya Hepatite C | Gukoresha ibiyobyabwenge | Indwara ya Hepatite C. | Ku ya 13 Ugushyingo 2018 | Icyiciro cya 4 |
NCT02103569 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mata 2014 | Icyiciro cya 1 |
NCT02772744 | Kaminuza ya Zagazig | Kaminuza ya Cairo | Indwara ya Hepatite C. | Ku ya 1 Ugushyingo 2017 |
|
NCT01718158 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mutarama 2013 | Icyiciro cya 3 |
NCT02496078 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Kanama 2015 | Icyiciro cya 3 |
NCT01425970 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Gicurasi 2012 | Icyiciro cya 2 |
NCT01471574 | Bristol-Myers Squibb | Indwara ya Hepatite C, Ubwoko bwa 1 | Ukuboza 2011 | Icyiciro cya 3 |
NCT01573351 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Gicurasi 2012 | Icyiciro cya 3 |
NCT01938625 | Janssen R&D Irlande | Indwara ya Hepatite C, idakira | Ku ya 12 Ukuboza 2013 | Icyiciro cya 2 |
NCT01492426 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mutarama 2012 | Icyiciro cya 3 |
NCT03480932 | Johns Hopkins Bloomberg Ishuri ryubuzima rusange | Ikigo cyigihugu gishinzwe kurwanya ibiyobyabwenge (NIDA) | Ikigo cya YR Gaitonde gishinzwe ubushakashatsi nuburezi kuri sida | Indwara ya Hepatite C, idakira | Ku ya 2 Gashyantare 2018 | Icyiciro cya 2 | Icyiciro cya 3 |
NCT03163849 | Kaminuza ya Assiut | Indwara ya Hepatite idakira c | Ku ya 1 Nzeri 2019 | Icyiciro cya 3 |
NCT01581203 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Gicurasi 2012 | Icyiciro cya 3 |
NCT01492504 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ku ya 7 Gashyantare 2012 |
|
NCT03686722 | Mohamed Raslan | Ain Shams University | Ikigo cy’ubushakashatsi ku biyobyabwenge, Cairo, Misiri | Indwara ya Diyabete, Ubwoko bwa 2 | Indwara ya Hepatite C | Imiti | Ku ya 9 Nzeri 2017 | Icyiciro cya 1 |
NCT02262728 | Janssen Ubushakashatsi & Iterambere, LLC | Indwara ya Hepatite C, idakira | Ku ya 30 Nzeri 2014 | Icyiciro cya 2 |
NCT02349048 | Janssen Ubushakashatsi & Iterambere, LLC | Virusi ya Hepatite C. | Mutarama 2015 | Icyiciro cya 2 |
NCT03882307 | Kaminuza ya Assiut | Indwara ya Hepatite C, idakira | Gicurasi 2020 | Icyiciro cya mbere |
NCT02758509 | Parc de Salut Mar | Indwara ya Hepatite idakira C | Cirrhose | Ku ya 1 Mutarama 2010 |
|
NCT01795911 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Werurwe 2013 | Icyiciro cya 2 |
NCT03549832 | Kaminuza ya Assiut | Kaminuza ya Sohag | Kaminuza yo mu majyepfo | Guhuza HCV | Ku ya 1 Mutarama 2018 | Ntabwo ari ngombwa |
NCT02161939 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. |
| |
NCT01309932 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Werurwe 2011 | Icyiciro cya 2 |
NCT01995266 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ku ya 28 Gashyantare 2014 | Icyiciro cya 3 |
NCT02640157 | AbbVie | Indwara ya Hepatite idakira C | Virusi ya Hepatite C | Genotype ya 3 Hepatite C. | Ukuboza 2015 | Icyiciro cya 3 |
NCT02032875 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Werurwe 2014 | Icyiciro cya 3 |
NCT02624063 | Kaminuza nkuru ya São Paulo | Indwara ya Hepatite C, idakira | Ukuboza 2015 | Icyiciro cya 4 |
NCT00546715 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. | Ugushyingo 2007 | Icyiciro cya 1 | Icyiciro cya 2 |
NCT01718145 | Bristol-Myers Squibb | Indwara ya Hepatite C Yanduye | Ugushyingo 2012 | Icyiciro cya 3 |
NCT01616524 | Bristol-Myers Squibb | Virusi ya Hepatite C (HCV) | Nyakanga 2012 | Icyiciro cya 3 |
NCT02032901 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mutarama 2014 | Icyiciro cya 3 |
NCT03540212 | Kaminuza ya Ain Shams | Indwara idakira ya HCV | Ku ya 10 Ukuboza 2017 | Icyiciro cya 2 | Icyiciro cya 3 |
NCT02097966 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. |
| |
NCT02596880 | Ishuri Rikuru ry'Ubuvuzi rya Tehran | Indwara ya Hepatite C | Cirrhose | Nzeri 2015 | Icyiciro cya 3 |
NCT04019717 | Atea Pharmaceuticals, Inc. | Indwara ya Hepatite C | Indwara ya Hepatite C, idakira | Indwara ya Hepatite idakira C | Indwara ya Hepatite C | Indwara ya HCV | Ku ya 20 Kamena 2019 | Icyiciro cya 2 |
NCT02992457 | Kaminuza ya Tanta | Indwara ya Hepatite C. | Mutarama 2015 | Icyiciro cya 4 |
NCT03547895 | Kaminuza ya Zagazig | Indwara ya Cirrhose | Ku ya 1 Kamena 2015 | Ntabwo ari ngombwa |
NCT03004625 | Ibitaro by’Urwibutso rwa Kaohsiung Chung-Ho | Ibitaro by’Urwibutso rwa Chang Gung | Ibitaro bya Kaminuza bya Tayiwani | Ibitaro Bikuru by’abasirikare ba Taipei, Tayiwani | Ibitaro bya Kaminuza by’ubuvuzi mu Bushinwa | Ibitaro bya Kaminuza bya Cheng-Kung | Indwara ya Hepatite C. | Ugushyingo 2016 | Icyiciro cya 3 |
NCT01051414 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mata 2010 | Icyiciro cya 2 |
NCT02309450 | Ikigo cy’igihugu cy’ubuzima n’ubushakashatsi mu Bufaransa-Ikigo cy’igihugu cy’Ubufaransa gishinzwe ubushakashatsi kuri sida na virusi ya Hepatite (Inserm-ANRS) | Bristol-Myers Squibb | Indwara ya Hepatite C Virusi Yanduye 4 | Ukuboza 2014 | Icyiciro cya 2 |
NCT01628692 | Bristol-Myers Squibb | Janssen Ubushakashatsi & Iterambere, LLC | Virusi ya Hepatite C. | Nyakanga 2012 | Icyiciro cya 2 |
NCT03186313 | Ibitaro byumwijima byo muri Egiputa | Ibitaro bya Wadi El Nil | Indwara ya Hepatite C. | Nzeri 2016 | Icyiciro cya 3 |
NCT03063723 | Ibitaro bya gatatu bishamikiyeho, Sun Yat-Sen University | Indwara ya Hepatite idakira C (Disorder) | Ku ya 1 Mutarama 2016 |
|
NCT00983957 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. | Ukwakira 2009 | Icyiciro cya 1 |
NCT01725542 | Ikigo cy’igihugu cy’ubuzima n’ubushakashatsi mu Bufaransa-Ikigo cy’igihugu cy’Ubufaransa gishinzwe ubushakashatsi kuri sida na virusi ya Hepatite (Inserm-ANRS) | Bristol-Myers Squibb | Kwandura HCV-VIH | Ukuboza 2012 | Icyiciro cya 2 |
NCT02282709 | Urufatiro rwubushakashatsi bwumwijima | Indwara ya Hepatite idakira C. | Gashyantare 2014 | Icyiciro cya 3 |
NCT02032888 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Gashyantare 2014 | Icyiciro cya 3 |
NCT03247296 | Kaminuza ya MTI | Indwara ya Hepatite C. | Ku ya 28 Gashyantare 2017 |
|
NCT01389323 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Nzeri 2011 | Icyiciro cya 3 |
NCT02556086 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2015 | Icyiciro cya 2 |
NCT01741545 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Ku ya 31 Werurwe 2013 | Icyiciro cya 3 |
NCT01866930 | Bristol-Myers Squibb | Indwara ya Hepatite C idakira | Ku ya 11 Nyakanga 2013 | Icyiciro cya 3 |
NCT02268864 | Janssen-Cilag Mpuzamahanga NV | Indwara ya Hepatite C, idakira | Mutarama 2015 | Icyiciro cya 2 |
NCT01797848 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Kamena 2014 | Icyiciro cya 3 |
NCT03166280 | Eman Sayed Hassan Abd Allah | Kaminuza ya Assiut | Indwara ya Hepatite C. | Kamena 2017 |
|
NCT02159352 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Kamena 2014 | Icyiciro cya 1 |
NCT01125189 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Nyakanga 2010 | Icyiciro cya 2 |
NCT03748745 | Nanjing Sanhome Pharmaceutical, Co, Ltd. | Imikoreshereze yibiyobyabwenge | Ku ya 19 Ugushyingo 2018 | Icyiciro cya 1 |
NCT01012895 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. | Ukuboza 2009 | Icyiciro cya 2 |
NCT02565888 | Kaminuza ya Radboud | Indwara ya Hepatite C | VIH | Ugushyingo 2015 | Icyiciro cya 1 |
NCT02555943 | Ikigo cyubushakashatsi bwubuzima nubuzima | Beijing 302 Ibitaro | Ibitaro bya Nanfang bya kaminuza yubuvuzi bwamajyepfo | Indwara ya Hepatite C idakira | Guhuza HBV | Hepatite B Reactivation | Gashyantare 2015 | Icyiciro cya 2 | Icyiciro cya 3 |
NCT02304159 | Tarek I. Hassanein, MD, FACP, FAG, AGAF | Ikigo cy’ubushakashatsi cya Californiya | Indwara ya Hepatite C | Cirrhose | Mutarama 2015 | Icyiciro cya 4 |
NCT02580474 | Indirimbo ya Myeong Jun | Bristol-Myers Squibb | Ibitaro bya Kaminuza ya Soonchunhyang | Dankook | Ibitaro bya Kaminuza bya Chungnam | Ibitaro bya Koniang | Ibitaro bya Kaminuza bya Eulji | , Koreya | Ibitaro bya Severance | Ibitaro bya Kaminuza bya Koreya | Ibitaro Bikuru bya Eulji | Kaminuza Gatolika ya Koreya | Indwara ya Hepatite C. | Gashyantare 2016 | Icyiciro cya 4 |
NCT02104843 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Mata 2014 | Icyiciro cya 1 |
NCT01428063 | Bristol-Myers Squibb | Indwara ya Hepatite C Yanduye | Nzeri 2011 | Icyiciro cya 2 |
NCT02123654 | Bristol-Myers Squibb | Indwara ya Hepatite C Yanduye | Mata 2014 | Icyiciro cya 3 |
NCT02565862 | Kaminuza ya Radboud | Indwara ya Hepatite C | Indwara ya Diyabete | Kurwanya insuline | Mutarama 2016 | Icyiciro cya 1 |
NCT04211844 | Kaminuza ya Ain Shams | Indwara ya Hepatite idakira C. | Ku ya 1 Ukwakira 2019 |
|
NCT00874770 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Kamena 2009 | Icyiciro cya 2 |
NCT03883698 | Ishuri Rikuru ry'Ubuvuzi rya Sanjay Gandhi | Kunanirwa kw'impyiko, karande | Hepatite C. | Ku ya 15 Werurwe 2019 | Icyiciro cya 3 |
NCT01448044 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Ukuboza 2011 | Icyiciro cya 3 |
NCT01359644 | Bristol-Myers Squibb | Pharmasset | Indwara ya Hepatite idakira C. | Kamena 2011 | Icyiciro cya 2 |
NCT01842451 | Imiti ya Vertex Yashizwemo | Indwara ya Hepatite idakira C | CHC | HCV | Indwara ya Hepatite C. | Kamena 2013 | Icyiciro cya 2 |
NCT02762448 | Ibitaro bya Komine ya Tainan | Indwara ya Hepatite c | Nyakanga 2016 |
|
NCT02473211 | Ikigo cyubushakashatsi bwubuzima nubuzima | Beijing 302 Ibitaro | Indwara ya Hepatite C idakira | Mutarama 2015 | Icyiciro cya 2 | Icyiciro cya 3 |
NCT01455090 | Bristol-Myers Squibb | Indwara ya Hepatite idakira C. | Ku ya 30 Ugushyingo 2011 | Icyiciro cya 2 |
NCT03490097 | Kaminuza ya Ain Shams | Indwara ya Hepatite idakira c | Indwara ya Metabolic | Ku ya 1 Ukuboza 2017 | Icyiciro cya 2 | Icyiciro cya 3 |
NCT01170962 | Bristol-Myers Squibb | Virusi ya Hepatite C. | Kanama 2010 | Icyiciro cya 2 |
NCT02333292 | Ibitaro bya Kaminuza bya Valme | Ibitaro del SAS de Jerez | Ibitaro Bikuru bya Universitario Elche | Ibitaro La Línea de la Concepción | Complexo Hospitalario Universitario de A Coruña | Ibitaro bya Figueres | Ibitaro Universitario Puerto Real | Ibitaro Universitario Virgen de la Victoria | Ibitaro Universitario de Canarias | Ibitaro Bikuru bya Universitario de Alicante | Ibitaro Universitario Araba | Ibitaro Royo Vilanova | Ibitaro Universitario de Burgos | Complejo Hospitalario Universitario de Huelva | Ibitaro Universitario Reina Sofia de Cordoba | Ibitaro Universitario Virgen Macarena | Complexo Hospitalario Universitario de Vigo | Clinica Universidad de Navigo | Navarra | Ibitaro Clinico Universitario San Cecilio | Ibitaro Universitario La Fe | Ibitaro Bikuru Universitario de Valencia | Ibitaro Universitario Infanta Leonor | Ibitaro Universitario de Gran Canaria | Ibitaro Bikuru bya Universitario Santa Lucía | Centro Penitenciario Alicante 1 | Ibitaro bya Universitario Carlos Haya | la L.uz | Ibitaro Bikuru bya Universitario de Castellón | Ibitaro Parc Taulí, Sabadell | Indwara ya Hepatite C idakira | Ukuboza 2014 |
|
NCT03200184 | Ishuri Rikuru ry'Ubuvuzi rya Tehran | Indwara ya Hepatite C. | Ku ya 1 Nzeri 2016 | Icyiciro cya 4 |
NCT03188276 | Ibitaro bya gatatu bishamikiyeho, Sun Yat-Sen University | Indwara ya Hepatite idakira C. | Ku ya 1 Gashyantare 2016 | Icyiciro cya mbere |
NCT01830205 | Bristol-Myers Squibb | Indwara ya Hepatite C. | Nzeri 2012 | Icyiciro cya 1 |
Icyifuzo18Imishinga yo gusuzuma ireme ryemejwe4, na6imishinga iremezwa.
Sisitemu mpuzamahanga yo gucunga neza ubuziranenge yashyizeho urufatiro rukomeye rwo kugurisha.
Igenzura ryiza rinyura mubuzima bwose bwibicuruzwa kugirango hamenyekane ingaruka nziza nubuvuzi.
Itsinda ryumwuga ushinzwe kugenzura ibikorwa byujuje ubuziranenge mugihe cyo gusaba no kwiyandikisha.