Amavu n'amavuko

Canagliflozin ni igitabo gishya, gifite imbaraga, kandi gitoranya cyane sodium glucose co-transport (SGLT) 2 inhibitor [1].Byaragaragaye ko Canagliflozin ishobora kongera inkari glucose isohoka mu kugabanya glucose yimpyiko no kugabanya glucose yongeye kuyungurura [2].

Canagliflozin yerekanwe kubuza gufata Na + -guhuza 14C-AMG muri CHO-hSGLT2, CHO-imbeba SGLT2 na CHO-imbeba SGLT2 ifite IC50 ifite agaciro ka 4.4, 3.7 na 2.0 nM, [1].

Bivugwa ko Canagliflozin igabanya urugero rwamaraso glucose (BG) ikabije bitewe na db / db Imbeba na Zucker ibinure bya Diyabete (ZDF).Byongeye kandi, canagliflozin yerekanye ko igabanya igipimo cy’ubuhumekero, hamwe nuburemere bwumubiri mu mbeba za DIO n'imbeba ZDF [1].

Canagliflozin irashobora gufatwa mu kanwa [1].

Reba:
. kuri glucose, glycemia, nuburemere bwumubiri mubyitegererezo byinyamaswa na diabete.PLOS Umwe.2012; 7 (2): e30555
[2] Sarnoski-Brocavich S, Hilas O. Canagliflozin (Invokana), Umukozi wo mu kanwa wa Diyabete yo mu bwoko bwa 2.P T. 2013 Ugushyingo; 38 (11): 656-66

Ibicuruzwa byatanzwe

Bahia Abbas Moussa, Marianne Alphonse Mahrouse, n'abandi..Spectrochimica Acta Igice A: Molecular na Biomolecular Spectroscopy Iraboneka kumurongo 20 Kamena 2018.

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