Bictegravir 1611493-60-7
Ibisobanuro
Bictegravir nigitabo gishya, cyangiza cyane virusi ya VIH-1 hamwe na IC50 ya 7.5 nM.
Muri Vitro
Bictegravir (BIC) ibuza ibikorwa byo kohereza umurongo hamwe na IC50 ya 7.5± 0.3 nM. Ugereranije no kubuza ibikorwa byo kwimura imirongo, Bictegravir nintege nke cyane ya inhibitor ya 3′-gutunganya ibikorwa bya VIH-1 IN, hamwe na IC50 ya 241±51 nM. Bictegravir yongerera imbaraga uruziga rwa 2-LTR ~ inshuro 5 ugereranije no kugenzura urw'agashinyaguro kandi igabanya ibicuruzwa biva mu mahanga byinjira mu ngirabuzimafatizo zanduye inshuro 100. Bictegravir irabuza cyane kwandura virusi ya VIH-1 muri selile MT-2 na MT-4 hamwe na EC50s ya 1.5 na 2.4 nM. Bictegravir yerekana ingaruka zikomeye za virusi muri CD4 + T ya lymphocytes na macrophage ikomoka kuri monocyte, hamwe na EC50s ya 1.5±0.3 nM na 6.6±4.1 nM, kimwe, cyagereranywa nagaciro kabonetse mumirongo ya T-selile [1].
MCE ntabwo yemeje ubwigenge ubu buryo. Nibisobanuro gusa.
| Umubare wa NCT | Umuterankunga | Imiterere | Itariki yo gutangiriraho | Icyiciro |
| NCT03998176 | Kaminuza ya Nebraska | Ubumenyi bwa Galeedi | VIH-1-kwandura | Ku ya 9 Ukwakira 2019 | Icyiciro cya 4 |
| NCT03789968 | Kaminuza ya Thomas Jefferson | Kaminuza ya Maryland, Parike ya Koleji | Ubuzima bwa Kaminuza ya Indiana | Ikigo cy’ibitaro bya Brooklyn | Kaminuza ya Illinois i Chicago | Kaminuza ya Nova y’Amajyepfo y’Amajyepfo | Kaminuza ya Californiya, San Francisco | VIH + SIDA | Ku ya 1 Nzeri 2019 | |
| NCT04249037 | Kaminuza ya Colorado, Denver | Ubumenyi bwa Galeedi | VIH + SIDA | Ku ya 1 Werurwe 2020 | Ntabwo ari ngombwa |
| NCT04132674 | Ikigo cyita ku ndwara zanduza Vancouver | Indwara ya immunodeficiency ya muntu I Yanduye | Gukoresha ibiyobyabwenge | Ku ya 26 Ugushyingo 2018 | Icyiciro cya 4 |
| NCT04054089 | Cristina Mussini | Kaminuza ya Modena na Reggio Emilia | Kwandura virusi itera SIDA | Nzeri 2019 | Icyiciro cya 4 |
| NCT04155554 | Azienda Ospedaliera Universitaria Senese | Kaminuza Gatolika yumutima Mutagatifu | Ospedale Policlinico San Martino | Azienda Ospedaliera San Paolo | Ospedale Amedeo di Savoia | VIH-1-kwandura | Ku ya 29 Mutarama 2020 | Icyiciro cya 3 |
| NCT02275065 | Ubumenyi bwa Galeedi | Kwandura VIH-1 | Ukwakira 2014 | Icyiciro cya 1 |
| NCT03711253 | Kaminuza yo mu majyepfo ya California | Kwandura virusi itera SIDA | Ku ya 14 Ukwakira 2019 | Icyiciro cya 4 |
| NCT02400307 | Ubumenyi bwa Galeedi | VIH | Ku ya 17 Mata 2015 | Icyiciro cya 1 |
| NCT03499483 | Ubuzima bwabaturage Fenway | Kwirinda virusi itera SIDA | Ku ya 24 Mutarama 2019 | Icyiciro cya 4 |
| NCT03502005 | Midland Research Group, Inc. | Ubumenyi bwa Galeedi | Virusi ya immunodeficiency ya muntu | Ku ya 1 Werurwe 2018 | Icyiciro cya 4 |
Imiterere yimiti
Icyifuzo18Imishinga yo gusuzuma ireme ryiza yemejwe4, na6imishinga iremezwa.
Sisitemu mpuzamahanga yo gucunga neza ubuziranenge yashyizeho urufatiro rukomeye rwo kugurisha.
Igenzura ryiza rinyura mubuzima bwose bwibicuruzwa kugirango hamenyekane ingaruka nziza nubuvuzi.
Itsinda rishinzwe kugenzura ibikorwa byumwuga rishyigikira ubuziranenge busabwa mugihe cyo gusaba no kwiyandikisha.
Koreya Countec Amacupa yo gupakira
Tayiwani CVC Icupa ryuzuye
Ubutaliyani CAM Ubuyobozi bwo gupakira
Imashini yo Kudage Fette
Ubuyapani Viswill Tablet Detector
Icyumba cyo kugenzura DCS
