Amavu n'amavuko

Agomelatine ni agonist ya reseptor ya melatonin akaba na antagonist ya serotonine 5-HT2C yakira hamwe na Ki agaciro ka 0.062nM na 0.268nM na IC50 agaciro ka 0.27μM, kuri MT1, MT2 na 5-HT2C [1].

Agomelatine ni antidepressant idasanzwe kandi yatunganijwe mu kuvura indwara zikomeye zo kwiheba (MDD). Agomelatine ihitamo kurwanya 5-HT2C. Irerekana isano rito kubantu bakoronijwe 5-HT2A na 5-HT1A. Kubakira melatonin, agomelatine yerekana isano isa na MT1 na MT2 yakoronijwe hamwe na Ki agaciro ka 0.09nM na 0.263nM. Mu bushakashatsi bwa vivo, agomelatine itera kwiyongera kurwego rwa dopamine na noradrenaline binyuze mukubuza kwinjiza 5-HT2C. Byongeye kandi, imiyoborere ya agomelatine irwanya igabanuka ryatewe no kugabanuka kwa kurya kwa sucrose muburyo bwimbeba yo kwiheba. Uretse ibyo, agomelatine igabanya imbaraga zo guhangayika muburyo bwo guhangayika [1].

Reba:
[1] Zupancic M, Guilleminault C. Agomelatine. Ibiyobyabwenge bya CNS, 2006, 20 (12): 981-992.

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