Nka anticagulant yo mu kanwa, rivaroxaban yakoreshejwe cyane mukurinda no kuvura indwara zifata imitsi no gukumira indwara ya stroke muri fibrillation idafite agaciro.Kugirango ukoreshe rivaroxaban mu buryo bushyize mu gaciro, ugomba kumenya byibuze izi ngingo 3.
I. Itandukaniro riri hagati ya rivaroxaban nizindi miti igabanya ubukana Muri iki gihe, imiti igabanya ubukana ikoreshwa mu kanwa harimo warfarin, dabigatran, rivaroxaban nibindi.Muri byo, dabigatran na rivaroxaban bita anticoagulants yo mu kanwa (NOAC).Warfarin, cyane cyane ikora anticoagulant muguhagarika synthesis yibintu bya coagulation II (prothrombin), VII, IX na X. Warfarin nta ngaruka igira kumikorere ya coagulation bityo ikagira buhoro buhoro ibikorwa.Dabigatran, cyane cyane binyuze mukubuza ibikorwa bya trombine (prothrombin IIa), bigira ingaruka mbi.Rivaroxaban, cyane cyane binyuze mukubuza ibikorwa bya coagulation factor Xa, bityo bikagabanya umusaruro wa trombine (coagulation factor IIa) kugirango igire ingaruka mbi, ntabwo bigira ingaruka kumikorere ya trombine imaze gukorwa, bityo ntigire ingaruka nke mumikorere ya hemostasis ya physiologique.
2. Ibimenyetso byerekana ivuriro rya rivaroxaban imitsi yimitsi ya endoteliyale, umuvuduko wamaraso, umuvuduko ukabije wamaraso nibindi bintu bishobora gutera trombose.Mu barwayi bamwe b'amagufwa, kubaga ikibuno cyangwa ivi biragerwaho cyane, ariko bahita bapfa iyo bavuye mu buriri nyuma y'iminsi mike babagwa.Ibi birashoboka kubera ko umurwayi yagize trombose ndende nyuma yo kubagwa hanyuma agapfa azize embolisme yimpyisi iterwa na trombus idacitse.Rivaroxaban, yemerewe gukoreshwa mu barwayi bakuze barimo kubagwa ikibuno cyangwa ivi kugira ngo birinde indwara ya trombose (VTE);no kuvura imitsi yimbitse (DVT) kubantu bakuze kugirango bagabanye ibyago byo kongera kwandura na embolisme yimpyiko (PE) nyuma ya DVT ikaze.Fibrillation ya Atriel ni umutima udasanzwe wumutima hamwe nubwiyongere bugera kuri 10% kubantu barengeje imyaka 75.Abarwayi bafite fibrillation atriyale bafite amaraso yo guhagarara muri atriya no gukora uturemangingo, dushobora kuvaho kandi bigatera inkorora.Rivaroxaban, yemerewe kandi irasabwa abarwayi bakuze bafite fibrillation ya atrivulaire kugirango bagabanye ibyago byo kwandura indwara ya embolisme.Imikorere ya rivaroxaban ntabwo iri munsi ya warfarin, indwara yo kuva amaraso munda iri munsi ya warfarin, kandi ntabwo buri gihe hakurikiranwa ubukana bwa anticoagulation, nibindi.
3. Ingaruka zo kurwanya antivagulant ya rivaroxaban zirahanurwa, hamwe nidirishya ryagutse ryo kuvura, ntirirundanya nyuma yimiti myinshi, kandi imikoranire mike nibiyobyabwenge nibiryo, kubwibyo kugenzura buri gihe ntabwo ari ngombwa.Mubihe bidasanzwe, nko gukekwa kurenza urugero, ibintu bikomeye byo kuva amaraso, kubagwa byihutirwa, kuba ibintu bya tromboembolique cyangwa gukekwa kutubahiriza amategeko, kugena igihe cya prothrombine (PT) cyangwa kugena ibikorwa birwanya ibintu Xa.Inama: Rivaroxaban ikoreshwa cyane na CYP3A4, ikaba insimburangingo ya poroteyine itwara P-glycoproteine ​​(P-gp).Kubwibyo, rivaroxaban ntigomba gukoreshwa ifatanije na itraconazole, voriconazole na posaconazole.