2. Thalidomide muri cachexia yibibyimba
Oncologic cachexia, syndrome ya kanseri yateye imbere irangwa no kubura anorexia, kugabanuka kw'imitsi no kugabanya ibiro, ni ikibazo gikomeye mu kuvura indwara ya kanseri yateye imbere.
Bitewe no kubaho igihe gito nubuzima bubi bwabarwayi barwaye kanseri yateye imbere, umubare w’amasomo mu bushakashatsi bw’ubuvuzi ni muto, kandi ubushakashatsi bwinshi bwasuzumye gusa ingaruka zigihe gito n’ingaruka mbi za thalidomide, bityo rero igihe kirekire- ijambo efficacy ningaruka ndende mbi za thalidomide mukuvura cachexia ya oncologic iracyakeneye gushakishwa mubigeragezo byamavuriro bifite ubunini bw'icyitegererezo.
3. Ingaruka mbi zijyanye no kuvura thalidomide
Ingaruka mbi nka chimiotherapie zijyanye no kugira isesemi no kuruka birashobora kugira ingaruka kumikorere ya chimiotherapie kandi bikagabanya imibereho yabarwayi. Nubwo neurokinin 1 yakira antagonistes irashobora kunoza cyane ingaruka mbi nko kugira isesemi no kuruka, kubivura no kubateza imbere biragoye kubera ubukungu bwabarwayi nizindi mpamvu. Kubwibyo rero, gushakisha imiti yizewe, ikora neza kandi ihendutse kugirango ikingire kandi ivure chimiotherapie iterwa no kugira isesemi no kuruka byabaye ikibazo cyihutirwa cyamavuriro.
4. Umwanzuro
Hamwe niterambere rihoraho ryubushakashatsi bwibanze nubuvuzi, ikoreshwa ryathalidomidemu kuvura ibibyimba bisanzwe byakomeje kwiyongera, kandi imikorere y’ubuvuzi n’umutekano byamenyekanye kandi bitanga ingamba nshya zo kuvura abarwayi. Thalidomide nayo ifite akamaro mukuvura ikibyimba cachexia hamwe na chimiotherapie ifitanye isano no kugira isesemi no kuruka. Mugihe cyubuvuzi bwuzuye bwo kuvura, ni ngombwa gusuzuma abaturage biganje hamwe nubwoko bwibibyimba bigira akamarothalidomidekuvura no gushaka biomarkers zerekana ingaruka zabyo n'ingaruka mbi.