Ruxolitinib ni ubwoko bwubuvuzi bwo mu kanwa bwitwa kinase inhibitor kandi bukoreshwa cyane cyane mu kuvura indwara nka graft-na-host-host, erythroblastose, na myelofibrosis yo mu rwego rwo hejuru kandi ishobora guteza ibyago byinshi, naho cream ya Ruxolitinib ni imiti y’indwara ya dermatologiya ikoreshwa. ku ruhu mu buryo butaziguye kugira ngo bavure eczema, vitiligo, dermatite ya Atopic, n'umuhondo. Nubwo amavuta ya Ruxolitinib na Ruxolitinib atandukanye cyane, baritiranya byoroshye kuko bafite izina risa. Uruganda rwa farumasi rwa Changzhou (CPF), ruyoboraRuxolitinibmu Bushinwa, hano isesengura itandukaniro riri hagati yabo ukurikije ibintu bitatu by'ingenzi bigufasha kumenya byinshi kuri bo.
1. Kwerekana
Ruxolitinibyemejwe na FDA mu Gushyingo 2011 na Komisiyo y’Uburayi muri Kanama 2012 kandi ni ubwoko bw’ibiyobyabwenge bigamije ibimenyetso bifatika. Ikoreshwa mu kuvura abarwayi bafite uburwayi bwubwoko butatu, harimo steroid-refractory acute graft-na-host host, erythroblastose, na myelofibrosis (MF). Ariko amavuta ya Ruxolitinib ari mubyiciro byiterambere kandi ananirwa kujya ku isoko, bityo rero niwo muti wingenzi wo kuvura indwara ya shin nu ruhara kandi nta bimenyetso byemewe kugeza ubu. Nyamara, ubushakashatsi bwerekanye ubuhanga bwa cream ya Ruxolitinib mu kuvura vitiligo, dermatite ya atopic no kogosha cyane.
2. Uburyo bwo gusaba
Ruxolitinib ni inzitizi ya kinase yo mu kanwa ikora nka molekile ntoya ya protein kinase ya JAK1 na JAK2, kandi niwo muti wa mbere wemejwe na FDA uvura myelofibrosis. Ariko amavuta ya Ruxolitinib ni cream yibanze ya cream itandukanye cyane na Ruxolitinib muburyo ikoreshwa.
3. Ingaruka kuruhande
Ruxolitinib ifite ingaruka zisobanutse. Ingaruka zikunda kuvura indwara zijyanye no kuvura indwara zijyanye no kuyikoresha ni ukugabanya umubare wa platel na anemia, kandi ingaruka zikunze kugaragara zitari hematologique ni petechiae, umutwe, no kubabara umutwe. Nyamara, cream ya Ruxolitinib iracyari mu mavuriro, bityo ingaruka zayo ntizamenyekana.
Menyesha CPF kugirango ubone Ruxolitinib ku giciro cyiza, kandi witabe gahunda yo gushaka abakozi bo kwa muganga kugirango ubone amavuta ya Ruxolitinib kubuntu.
Igihe cyo kohereza: Gicurasi-12-2022