Myelofibrosis (MF) yitwa myelofibrosis.Nindwara idasanzwe.Kandi icyabiteye ntikiramenyekana.Indwara zisanzwe zigaragara ni selile yumutuku wabana bato na anemia ya granulocytic hamwe numubare munini wamarira atemba.Icyifuzo cy'amagufwa yerekana ibyifuzo byumye, kandi ururenda rwagutse cyane kuburyo butandukanye bwa osteosclerose.
Myelofibrosis primaire (PMF) ni indwara ya myeloproliferative disorder (MPD) ya selile hematopoietic stem selile.Kuvura myelofibrosis yibanze irashyigikirwa, harimo no guterwa amaraso.Hydroxyurea irashobora gutangwa kuri trombocytose.Abarwayi bafite ibyago bike, simptomatic barashobora kugaragara batavuwe.
Ubushakashatsi bubiri butemewe bwa gatatu (STUDY1 na 2) bwakorewe kubarwayi barwaye MF (primaire MF, post-geniculocytose MF, cyangwa post-primaire trombocythemia MF).Muri ubwo bushakashatsi bwombi, abarwayi biyandikishije bari bafite splenomegaly byibura cm 5 munsi yurubavu kandi bari mu rugero ruciriritse (ibintu 2 byerekana) cyangwa ibyago byinshi (3 cyangwa byinshi byerekana ibintu) bakurikije ibipimo byumvikanyweho nitsinda mpuzamahanga (IWG).
Igipimo cyambere cya ruxolitinib gishingiye kumibare ya platel.15 mg kabiri kumunsi kubarwayi bafite platelet iri hagati ya 100 na 200 x 10 ^ 9 / L na 20 mg kabiri kumunsi kubarwayi bafite platine irenga 200 x 10 ^ 9 / L.
Igipimo cyihariye cyatanzwe ukurikije kwihanganira no gukora neza kubarwayi bafite platine iri hagati ya 100 na 125 x 10 ^ 9 / L, hamwe na dose ya 20 mg kabiri kumunsi;kubarwayi bafite platine ibara hagati ya 75 na 100 x 10 ^ 9 / L, 10 mg kabiri kumunsi;naho kubarwayi bafite platine ibarwa hagati ya 50 na munsi cyangwa irenga 75 x 10 ^ 9 / L, inshuro 2 kumunsi 5mg buri mwanya.
Ruxolitinibni umunwa JAK1 na JAK2 tyrosine kinase inhibitor yemejwe mu muryango w’ubumwe bw’ibihugu by’Uburayi muri Kanama 2012 kugira ngo bivure myelofibrosis hagati cyangwa ibyago byinshi, harimo myelofibrosis primaire, post-geniculocytose myelofibrosis na trombocythemia myelofibrosis.Kugeza ubu, ruxolitinib Jakavi yemerewe mu bihugu birenga 50 ku isi, harimo Umuryango w’ubumwe bw’ibihugu by’Uburayi, Kanada ndetse n’ibihugu byinshi byo muri Aziya, Ikilatini na Amerika yepfo.