Myelofibrosis (MF) yitwa myelofibrosis. Nindwara idasanzwe. Kandi icyateye indwara yacyo ntikiramenyekana. Indwara zisanzwe zigaragara ni selile yamaraso itukura yingimbi na granulocytic anemia hamwe numubare munini wamarira atemba atukura. Amagufa yo mu magufa yerekana ibyifuzo byumye, kandi ururenda rwagutse cyane kuburyo butandukanye bwa osteosclerose.
Myelofibrosis primaire (PMF) nindwara ya myeloproliferative disorder (MPD) ya selile hematopoietic stem selile. Kuvura myelofibrosis yibanze irashyigikirwa cyane cyane harimo no guterwa amaraso. Hydroxyurea irashobora gutangwa kuri trombocytose. Ibyago bike, abarwayi badafite ibimenyetso birashobora kugaragara batavuwe.
Ubushakashatsi bubiri buteganijwe mu cyiciro cya III (STUDY1 na 2) bwakorewe ku barwayi bafite MF (MF y'ibanze, nyuma ya geniculocytose MF, cyangwa nyuma ya primaire ya trombocythemia MF). Muri ubwo bushakashatsi bwombi, abarwayi biyandikishije bari bafite splenomegaly byibura cm 5 munsi y’urubavu kandi bari ku rugero ruciriritse (ibintu 2 byerekana) cyangwa ibyago byinshi (3 cyangwa byinshi byerekana ibintu) hakurikijwe ibipimo mpuzamahanga byumvikanyweho (IWG).
Igipimo cyambere cya ruxolitinib gishingiye kumibare ya platel. 15 mg kabiri kumunsi kubarwayi bafite platelet iri hagati ya 100 na 200 x 10 ^ 9 / L na 20 mg kabiri kumunsi kubarwayi bafite platine irenga 200 x 10 ^ 9 / L.
Dose ku giti cye yatanzwe hakurikijwe kwihanganira no gukora neza ku barwayi bafite platine iri hagati ya 100 na 125 x 10 ^ 9 / L, hamwe na dose ntarengwa 20 mg kabiri ku munsi; kubarwayi bafite platine ibarwa hagati ya 75 na 100 x 10 ^ 9 / L, mg 10 kabiri kumunsi; naho kubarwayi bafite platine ibara hagati ya 50 na munsi cyangwa munsi ya 75 x 10 ^ 9 / L, inshuro 2 kumunsi kuri 5mg buri mwanya.
Ruxolitinibni umunwa JAK1 na JAK2 tyrosine kinase inhibitor yemejwe mu muryango w’ubumwe bw’ibihugu by’Uburayi muri Kanama 2012 kugira ngo bivure myelofibrosis yo hagati cyangwa ishobora guteza ibyago byinshi, harimo myelofibrosis yibanze, nyuma ya geniculocytose myelofibrosis na trombocythemia myelofibrosis. Kugeza ubu, ruxolitinib Jakavi yemerewe mu bihugu birenga 50 ku isi, harimo Umuryango w’ubumwe bw’ibihugu by’Uburayi, Kanada ndetse n’ibihugu byinshi byo muri Aziya, Ikilatini na Amerika yepfo.