Ingamba zo kuvura myelofibrosis yibanze (PMF) zishingiye ku byiciro.Bitewe nuburyo butandukanye bwo kwivuza nibibazo bigomba gukemurwa kubarwayi ba PMF, ingamba zo kuvura zigomba kuzirikana indwara zumurwayi hamwe nubuvuzi bukenewe.Ubuvuzi bwambere hamwe na ruxolitinib (Jakavi / Jakafi) kubarwayi bafite ururenda runini rwerekanaga igabanuka ryimyanya ndangagitsina kandi ntirishingiye kumiterere ya mutation.Ubunini bunini bwo kugabanya intanga bwerekana neza neza.Mu barwayi bafite ibyago bike badafite uburwayi bukomeye bwo mu mavuriro, barashobora kugaragara cyangwa kwinjira mu mavuriro, hamwe no gusuzuma buri mezi 3-6.Ruxolitinib.
Kubarwayi hagati-ibyago-2 cyangwa abarwayi bafite ibyago byinshi, HSCT ya allogeneic.Niba transplantation itabonetse, ruxolitinib (Jakavi / Jakafi) irasabwa nkumurongo wambere wo kuvura cyangwa kwinjira mubizamini byubuvuzi.Ruxolitinib (Jakavi / Jakafi) niyo miti yonyine yemewe kwisi yose yibasira inzira ya JAK / STAT idakabije, indwara ya MF.Ubushakashatsi bubiri bwasohotse mu kinyamakuru New England Journal hamwe n'ikinyamakuru cya Leukemia & Lymphoma cyerekana ko ruxolitinib (Jakavi / Jakafi) ishobora kugabanya cyane iyi ndwara no kuzamura imibereho y'abarwayi barwaye PMF.Mu barwayi ba MF hagati y’ibyago-2 n’ibyago byinshi, ruxolitinib (Jakavi / Jakafi) yashoboye kugabanya ururenda, kunoza indwara, kunoza ubuzima, no kunoza indwara y’amagufwa, yujuje intego z’ibanze zo gucunga indwara.
PMF ifite amahirwe yo kwandura buri mwaka 0.5-1.5 / 100,000 kandi ifite prognoz mbi cyane ya MPNs zose.PMF irangwa na myelofibrosis na hematopoiesis ikabije.Muri PMF, fibroblast yo mu magufa ntabwo ikomoka kuri clon idasanzwe.Hafi ya kimwe cya gatatu cyabarwayi bafite PMF nta bimenyetso bafite mugihe cyo gusuzuma.Ibirego birimo umunaniro ukabije, kubura amaraso, kubura inda, gucibwamo bitewe no guhaga hakiri kare cyangwa splenomegaly, kuva amaraso, guta ibiro, no kuribwa hanze.Ruxolitinib.Kuri ubu ibiyobyabwenge biboneka mu bihugu birenga 50 ku isi.