Ingamba zo kuvura myelofibrosis yibanze (PMF) zishingiye ku byiciro. Bitewe nuburyo butandukanye bwo kwivuza nibibazo bigomba gukemurwa mu barwayi ba PMF, ingamba zo kuvura zigomba kuzirikana indwara z’umurwayi n’ibikenewe kwa muganga. Ubuvuzi bwambere hamwe na ruxolitinib (Jakavi / Jakafi) kubarwayi bafite ururenda runini byagaragaje igabanuka ryinshi ryintanga kandi ntirishingiye kumiterere ya mutation. Ubunini bunini bwo kugabanya intanga bwerekana neza neza. Ku barwayi bafite ibyago bike badafite uburwayi bukomeye bw’ubuvuzi, barashobora kugaragara cyangwa kwinjira mu bigeragezo by’amavuriro, bagasuzumwa buri mezi 3-6.Ruxolitinib.
Hagati-hagati-ibyago-2 cyangwa abarwayi bafite ibyago byinshi, HSCT ya allogeneic. Niba transplantation itaboneka, ruxolitinib (Jakavi / Jakafi) irasabwa nkuburyo bwa mbere bwo kuvura cyangwa kwinjira mubizamini byubuvuzi. Ruxolitinib (Jakavi / Jakafi) nicyo kiyobyabwenge cyonyine cyemewe kwisi yose yibasira inzira ya JAK / STAT idakabije, indwara ya MF. Ubushakashatsi bubiri bwasohotse mu kinyamakuru New England Journal na Journal of Leukemia & Lymphoma bwerekana ko ruxolitinib (Jakavi / Jakafi) ishobora kugabanya cyane iyi ndwara no kuzamura imibereho y’abarwayi bafite PMF. Mu barwayi bafite MF hagati y’ibyago-2 n’ibyago byinshi, ruxolitinib (Jakavi / Jakafi) yashoboye kugabanya ururenda, kunoza indwara, guteza imbere ubuzima, no kunoza indwara y’amagufwa, yujuje intego z’ibanze zo gucunga indwara.
PMF ifite amahirwe yo kwandura buri mwaka ya 0.5-1.5 / 100.000 kandi ifite prognoza mbi ya MPNs zose. PMF irangwa na myelofibrosis na hematopoiesis ikabije. Muri PMF, fibroblast yo mu magufa ntabwo ikomoka kuri clon idasanzwe. Hafi ya kimwe cya gatatu cyabarwayi bafite PMF nta bimenyetso bafite mugihe cyo kwisuzumisha. Ibirego birimo umunaniro ukabije, kubura amaraso, kubura inda, impiswi bitewe no guhaga hakiri kare cyangwa splenomegaly, kuva amaraso, guta ibiro, hamwe no kuribwa hanze.Ruxolitinib. Kuri ubu ibiyobyabwenge biboneka mu bihugu birenga 50 ku isi.