Kunanirwa k'umutima hamwe no kugabanya igice cyo gusohora (HFrEF) nubwoko bukomeye bwo kunanirwa k'umutima, kandi ubushakashatsi bwakozwe na China HF bwerekanye ko 42% byananiranye kumutima mubushinwa ari HFrEF, nubwo ibyiciro byinshi byo kuvura imiti biboneka kuri HFrEF kandi byagabanije ibyago y'urupfu no gushyirwa mubitaro kubera kunanirwa k'umutima kurwego runaka.Nyamara, abarwayi bafite ibyago byinshi byo kunanirwa k'umutima bikabije, ibintu bipfa bikomeza kuba 25% naho prognoz ikomeza kuba mibi.Kubwibyo, haracyakenewe byihutirwa imiti mishya yo kuvura HFrEF, na Vericiguat, imashini itera imbaraga ya guanylate cyclase (sGC), yakozwe mubushakashatsi bwa VICTORIA kugirango harebwe niba Vericiguat ishobora kunoza imenyekanisha ry’abarwayi bafite HFrEF.Ubushakashatsi nubushakashatsi bwinshi, buteganijwe, bubangikanye-itsinda, bugenzurwa na perezidansi, impumyi-ebyiri, ibyabaye-biterwa, icyiciro cya gatatu cy’ubuvuzi.Yayobowe n’ikigo cya VIGOR muri Kanada ku bufatanye n’ikigo cy’ubushakashatsi cy’ubuvuzi cya Duke, ibigo 616 byo mu bihugu 42 n’uturere, harimo Uburayi, Ubuyapani, Ubushinwa na Amerika, bitabiriye ubwo bushakashatsi.Ishami ryumutima ryacu ryatewe inkunga yo kwitabira.Umubare w'abarwayi 5.050 bafite ikibazo cyo kunanirwa k'umutima bafite imyaka 18, NYHA icyiciro cya II-IV, EF <45%, hamwe na peptide natriuretic peptide (NT-proBNP) mu minsi 30 mbere yo gutoranya, kandi bari mu bitaro kubera ikibazo cy'umutima. mugihe cy'amezi 6 mbere yo gutoranya cyangwa kuba yaranduye diuretique yatewe no kunanirwa k'umutima mugihe cy'amezi 3 mbere yo gutoranya abantu bariyandikishije mubushakashatsi, bose bakira ESC, AHA / ACC, hamwe nubuyobozi bwihariye bwigihugu / akarere basabye ubuvuzi.Abarwayi batoranijwe mu kigereranyo cya 1: 1 n'amatsinda abiri barahabwaVericiguat(n = 2526) na placebo (n = 2524) hejuru yubuvuzi busanzwe.
Iherezo ryibanze ryubushakashatsi kwari uguhuza urupfu rwumutima nimiyoboro y'amaraso cyangwa ibitaro byambere byananiye umutima;icyiciro cya kabiri cyarimo ibice bigize iherezo ryambere, icyambere nicyakurikiyeho kunanirwa kumutima mubitaro (ibyabaye nibisubirwamo), iherezo ryimpamvu zose zurupfu cyangwa kunanirwa kumutima mubitaro, hamwe nimpamvu zose zurupfu.Mugihe cyo gukurikiranwa hagati y'amezi 10.8, habayeho kugabanuka ugereranije 10% mumpera yambere y'urupfu rw'umutima n'imitsi cyangwa ibitaro bya mbere byananiranye mubitaro mumatsinda ya Vericiguat ugereranije nitsinda rya placebo.