Ruxolitinibni ubwoko bwibiyobyabwenge bya kanseri.Ikoreshwa cyane cyane kubuza gukora inzira ya JAK-STAT yerekana inzira no kugabanya ibimenyetso bihagarika iterambere ridasanzwe, bityo bikagera kubikorwa byo kuvura.Cyakora mukubuza umubiri wawe kubyara ibintu bita gukura.Ntishobora gukiza indwara imwe gusa mubice byo kuvura indwara ya hematologiya, ariko kandi irashobora kuvura neoplasme ya myeloproliferative classique (nanone yitwa BCR-ABL1-mbi MPNs), JAK exon 12 ihinduka, CALR, na APL, nibindi.
Ni ubuhe butumwa busabwa gutangira?
Irashobora gutera ingaruka zirimo na myelosuppression nayo, bikavamo indwara zidasanzwe, ariko zishobora kuba zikomeye nka neutropenia, trombocytopenia, leukemia na anemia.Hagomba rero kwitonderwa byumwihariko muguhitamo dosiye yo gutangira abarwayi.Icyifuzo cyo gutangira dose ya Ruxolitinib ahanini biterwa numubare wumurwayi wa PLT.Ku barwayi bafite platelet barenga 200, igipimo cyo gutangira ni 20 mg kabiri kumunsi;kubafite platelet babarirwa hagati ya 100 na 200, ikigereranyo cyo gutangira ni 15 mg kabiri kumunsi;Ku barwayi bafite platine ibara hagati ya 50 na 100, igipimo ntarengwa cyo gutangira ni 5 mg kabiri kumunsi.
Kwirinda mbere yo gufataRuxolitinib
Ubwa mbere, hitamo umuganga ufite uburambe bukomeye mubuvuzi hamwe na Ruxolitinib.Bwira muganga wawe niba ufite allergie, cyangwa niba ufite izindi allergie.Irashobora kuba irimo ibintu bidakora, bishobora gutera allergique cyangwa ibindi bibazo.
Icyakabiri, gerageza buri gihe kubara PLT yawe.Kubara amaraso yuzuye hamwe na platelet bigomba kwandikwa buri byumweru 2-4 uhereye igihe ufashe Ruxolitinib kugeza dosiye ihagaze neza, hanyuma ikapimwa niba ibimenyetso byubuvuzi bisaba.
Icya gatatu, hindura dosiye neza.Igipimo cyo gutangira ntigishobora guhinduka niba ufashe Ruxolitinib ariko ukagira platelet nkeya mukitangira.Iyo umubare wawe wa PLT uzamutse mugihe intego yo guhuza imiti ikomeza, urashobora kongera buhoro buhoro gukurikiza amabwiriza ya muganga witonze.
Hanyuma, bwira umuganga wawe amateka yubuvuzi, cyane cyane indwara ya myeloproliferative nkindwara zimpyiko, indwara yumwijima, na kanseri yuruhu.Ibindi biyobyabwenge cyangwa imiti bigomba gusimbuza Ruxolitinib niba udakwiriye.
Igihe cyo kohereza: Apr-25-2022