Ruxolitinibni ubwoko bwibiyobyabwenge bya kanseri. Ikoreshwa cyane cyane mukubuza gukora inzira ya signal ya JAK-STAT no kugabanya ibimenyetso bihagarika iterambere ridasanzwe, bityo bikagera kubikorwa byo kuvura. Cyakora mukubuza umubiri wawe kubyara ibintu bita ibintu bikura. Ntishobora gukiza indwara imwe gusa mubice byo kuvura indwara ya hematologiya, ahubwo ishobora no kuvura indwara ya myeloproliferative neoplasme ya kera (nanone yitwa MPRs ya BCR-ABL1-mbi), JAK exon 12 ihinduka, CALR, na APL, nibindi.
Ni ubuhe butumwa busabwa gutangira?
Irashobora gutera ingaruka zirimo na myelosuppression nayo, bigatuma habaho ivuriro ridasanzwe, ariko rishobora kuba rikomeye nka neutropenia, trombocytopenia, leukemia na anemia. Hagomba rero kwitabwaho cyane muguhitamo dosiye yo gutangira mugihe wandikira abarwayi. Icyifuzo cyo gutangira dose ya Ruxolitinib ahanini biterwa numubare wa PLT wumurwayi. Ku barwayi bafite platelet barenga 200, igipimo cyo gutangira ni 20 mg kabiri kumunsi; kubafite platine ibara hagati ya 100 na 200, igipimo cyo gutangira ni 15 mg kabiri kumunsi; Ku barwayi bafite platine ibara hagati ya 50 na 100, igipimo ntarengwa cyo gutangira ni 5 mg kabiri kumunsi.
Kwirinda mbere yo gufataRuxolitinib
Icyambere, hitamo umuganga ufite uburambe bukomeye mubuvuzi hamwe na Ruxolitinib. Bwira umuganga wawe niba ufite allergie kuri yo, cyangwa niba ufite izindi allergie. Irashobora kuba irimo ibintu bidakora, bishobora gutera allergie reaction cyangwa ibindi bibazo.
Icyakabiri, gerageza buri gihe kubara PLT yawe. Umubare wuzuye wamaraso hamwe numubare wa platel ugomba kwandikwa buri byumweru 2-4 kuva ufata Ruxolitinib kugeza dosiye ihagaze neza, hanyuma ikapimwa niba ibimenyetso byubuvuzi bibikeneye.
Icya gatatu, hindura dosiye neza. Igipimo cyo gutangira ntigishobora guhinduka niba ufashe Ruxolitinib ariko ukagira platelet nkeya mukitangira. Iyo umubare wawe wa PLT uzamutse mugihe intego yo guhuza imiti igenda itera imbere, urashobora kongera buhoro buhoro ikurikiza amabwiriza ya muganga witonze.
Hanyuma, bwira umuganga wawe amateka yubuvuzi, cyane cyane indwara ya myeloproliferative nkindwara zimpyiko, indwara zumwijima, na kanseri yuruhu. Indi miti cyangwa imiti igomba gusimbuza Ruxolitinib niba udakwiriye.
Igihe cyo kohereza: Apr-25-2022