Ku ya 19 Gicurasi 2022, Ikigo cy’igihugu gishinzwe ubuvuzi bw’Ubushinwa (NMPA) cyemeje gusaba isoko rya BayerVericiguat(2,5 mg, 5 mg, na 10 mg) munsi yizina rya Verquvo ™.

Uyu muti ukoreshwa ku barwayi bakuze bafite ibimenyetso simusiga byumutima bikagabanuka no kugabanya igice cyo gusohora (agace kasohotse <45%) bahagaze neza nyuma yimikorere iheruka kwishyurwa hamwe nubuvuzi bwimitsi, kugirango bigabanye ibyago byo gushyirwa mubitaro kubera kunanirwa k'umutima cyangwa kuvura byihutirwa byinjira mu mitsi.

Iyemezwa rya Vericiguat ryashingiye ku bisubizo byiza bivuye mu bushakashatsi bwa VICTORIA, bwerekanye ko Vericiguat ishobora kurushaho kugabanya ibyago by’impfu z’umutima n’imitsi ndetse no mu bitaro kubera kunanirwa k'umutima ku kigero cya 4.2% (ibyabaye bigabanya ingaruka / 100-by’abarwayi-imyaka) ku barwayi bafite umutima kunanirwa wagize ikibazo cyo kunanirwa k'umutima vuba aha kandi gihamye kumiti ivura imitsi hamwe no kugabanya igice cyo gusohora (agace kasohotse <45%).

Muri Mutarama 2021, Vericiguat yemerewe muri Amerika kuvura indwara zidakira z'umutima zidakira ku barwayi bafite uduce duto twa 45% nyuma yo guhura n'ikibazo cyo kunanirwa k'umutima.

Muri Kanama 2021, icyifuzo gishya cy’ibiyobyabwenge kuri Vericiguat cyakiriwe na CDE hanyuma gishyirwa mu bikorwa by’ibanze byo gusuzuma no kwemeza hashingiwe ku “miti yihutirwa y’amavuriro, imiti igezweho ndetse n’imiti mishya yo gukumira no kuvura indwara zikomeye zanduza kandi indwara zidasanzwe ”.

Muri Mata 2022, Amabwiriza ya 2022 AHA / ACC / HFSA agenga imiyoborere yo kunanirwa k'umutima, yatanzwe ku bufatanye n’ishuri rikuru ry’imitima ry’Abanyamerika (ACC), Ishyirahamwe ry’imitima y'Abanyamerika (AHA), na Sosiyete ishinzwe kunanirwa umutima muri Amerika (HFSA) . gutsindwa gukabije gushingiye kubuvuzi busanzwe.

Vericiguatni sGC (soluble guanylate cyclase) itera imbaraga hamwe nuburyo bushya bufatanije na Bayer na Merck Sharp & Dohme (MSD). Irashobora kwivanga muburyo bwimikorere ya selile yerekana ibimenyetso no gusana NO-sGC-cGMP inzira.

Ubushakashatsi bwibanze nubuvuzi bwerekanye ko NO-soluble guanylate cyclase (sGC) -cyclic guanosine monophosphate (cGMP) inzira yerekana inzira ishobora kuba intego yo kunanirwa k'umutima udakira no kuvura umutima. Mugihe cyimiterere yumubiri, iyi nzira yerekana inzira ninzira yingenzi igenga ubukanishi bwa myocardial, imikorere yumutima, hamwe nimikorere ya endoteliyale.

Mugihe cyimiterere ya pathophysiologique yo kunanirwa k'umutima, kwiyongera k'umuriro no kudakora neza kw'amaraso bigabanya OYA bioavailable na downstream cGMP synthesis. Kubura cGMP biganisha ku kudashyira mu gaciro k'imitsi iva mu mitsi, imitsi y'amaraso n'umutima, sclerose, fibrosis na hypertrophy, hamwe na mikorobe idakora neza, bityo bikarushaho gutera imvune ya myocardial igenda itera imbere, kwiyongera k'umuriro ndetse no kugabanuka kw'imikorere y'umutima n'impyiko.