Mu myaka yashize, kugurisha kwaapixabanyazamutse vuba, kandi isoko yisi yose yararenzerivaroxaban. Kubera Eliquis (apixaban) ifite akarusho kurenza warfarin mukurinda inkorora no kuva amaraso, na Xarelto (Rivaroxaban) yerekanaga gusa kutari hasi. Byongeye,Apixabanntibisaba guhindura dosiye igoye, kandi imiti iroroshye. Uru ruhererekane rwibibi rwatewerivaroxabangutakaza ikibanza ku isoko ryo muri Amerika.

Ariko, ku mugabane w'Ubushinwa,rivaroxabanifite ibimenyetso byinshi kwisi yose no mubushinwa. Igihe cya patenti kirangiriraho cyarivaroxabanni hafi, kandi kuboneka kw'ibiyobyabwenge bizatera abaturage barivaroxabanimiti rusange kugirango irenze cyane iyoApixaban.

Nk’uko imibare ya Xianda ibigaragaza, kugurisha isoko ry’imbere mu gihugu rivaroxaban muri 2018 byari miliyari 2.8. Nkuko byatangajwe na Farumasi ya Huahai, kugurisha isoko ryibitaro byimbere mu gihugurivaroxabanmuri 2018 yari miliyari 1.527.

Birumvikana ko urutonde rwibiyobyabwenge rusange bizatuma igabanuka rikabije ryigiciro cyumunsi umwerivaroxaban. Urebye ko muri NOACs zose, patenti yarivaroxabanibice birangira muri 2020 hakiri kare (patenti yaapixabanna dabigatran etexilate ni ndende Kumwanya muremure), ntagushidikanya ko bizagira akamaro mukuzamura byuzuyerivaroxabanimiti rusange yo gusimbuza warfarin. Niba igiciro cya buri munsi cyarivaroxabanimiti rusange itangizwa kuva 27,6 kugeza kuri 2.76, iyi nzira nayo izashimangirwa.

Umubare wibisabwa ureba gusa abarwayi bafite fibrillation atriel (AF) nabyo biratangaje. Umubare w'abarwayi bafite fibrillation atriyale mu Bushinwa ugera kuri miliyoni 10, muri bo abagera kuri miliyoni 2 ni abo mu bwoko bwa fibrillation ya valvular na hafi miliyoni 7 kuri fibrillation idafite agaciro. Ubushakashatsi bwakozwe mu mwaka wa 2016 Byagaragaye ko igipimo cyo gukangurira fibrillation atriyale ku mugabane w’Ubushinwa ari 40%, naho anticoagulation ni 30%. Rivaroxaban iroroshye kuyikoresha, ntisaba gukurikirana buri gihe ibipimo bya coagulation, kandi igipimo cya anticoagulation nacyo kizanozwa cyane. Byahanuwe ko ibiyobyabwenge rusange byarivaroxabanazaba ari ku mugabane w'Ubushinwa. Ingano yisoko ikoreshwa mubarwayi bafite fibrillation idafite agaciro na fibrillation atri: abarwayi miliyoni 7 * igipimo cya 30% anticoagulation * 50% byinjira * 2.76 yuan / kumunsi * iminsi 365 = miliyoni 157.

Byongeye kandi, amahirwe yisoko yo gukumira no kuvura abarwayi ba VTE ntasuzugurwa. Dukurikije imibare y’ikigo gishinzwe gukumira no kuvura VTE muri Amerika, umubare w’abarwayi ba VTE muri Amerika ugera ku 900.000 buri mwaka, kandi umubare w’abantu bapfa bazize VTE ugera ku 60.000 kugeza 100.000, kandi hari ibibazo birebire (nka DVT) abarwayi bangana na 50%, naho umubare wongeye kugaruka mumyaka 10 wagize 33%.

Bitewe n'ubusaza bw'Abashinwa, kandi umubare w'abaturage urenze inshuro 4 uw'Amerika (miliyari 1.395). Birashobora guhanurwa ko mubushinwa hari abarwayi ba VTE miliyoni 3.6. Dufashe ko igipimo cyamezi 3 yo kuvura yarivaroxabanni 80%, ingano yisoko ni: abarwayi miliyoni 3.6 * 80% yubuvuzi * 2.76 yuan / kumunsi * iminsi 92 = miliyoni 731.

Kubwibyo, kubara gusa ibimenyetso bibiri bya AF na VTE, ingano yisoko ryimbere yimiti rusange ya rivaroxaban igera kuri miliyari 2. Birahagije gutera uruganda rukora imiti murugo kwihutira gusaba kurutonde.

Twebwe,Uruganda rwa farumasi rwa Changzhou, kandiapxiabannarivaroxban, kandi byombi bifite DMF.Rivaroxabaniri gutunganywa gusaba CEP na WC.