Mu myaka yashize, kugurisha kwaapixabanzateye imbere vuba, kandi isoko yisi yose yararenzerivaroxaban.Kubera Eliquis (apixaban) ifite akarusho kuri warfarin mukurinda inkorora no kuva amaraso, na Xarelto (Rivaroxaban) yerekanaga gusa kutari hasi.Byongeye,Apixabanntibisaba guhindura dosiye igoye, kandi imiti iroroshye.Uru ruhererekane rwibibi rwatewerivaroxabangutakaza umwanya ku isoko ryo muri Amerika.

Ariko, ku mugabane w'Ubushinwa,rivaroxabanifite ibimenyetso byinshi kwisi yose no mubushinwa.Igihe cyo kurangiriraho igiherivaroxabanni hafi, kandi kuboneka kw'ibiyobyabwenge bizatera abaturage barivaroxabanimiti rusange kugirango irenze cyane iyoApixaban.

Dukurikije amakuru ya Xianda, mu mwaka wa 2018 igurishwa ry’isoko rya rivaroxaban ryari miliyari 2.8.Nkuko byatangajwe na Huahai Pharmaceutical, kugurisha isoko ryibitaro byo murugorivaroxabanmuri 2018 yari miliyari 1.527.

Birumvikana ko urutonde rwibiyobyabwenge rusanzwe bizatuma igabanuka rikabije ryumunsi umwe warivaroxaban.Urebye ko muri NOACs zose, patenti yarivaroxabanibice birangira muri 2020 hakiri kare (patenti yaapixabanna dabigatran etexilate ni ndende Kumwanya muremure), ntagushidikanya ko bizagira akamaro mukuzamura byuzuyerivaroxabanimiti rusange yo gusimbuza warfarin.Niba igiciro cya buri munsi cyarivaroxabanibiyobyabwenge rusange bitangizwa kuva 27,6 kugeza kuri 2.76, iyi nzira nayo izashimangirwa.

Umubare wibisabwa ureba gusa abarwayi bafite fibrillation atriel (AF) nabyo biratangaje.Umubare w'abarwayi bafite fibrillation atriale mu Bushinwa ni miliyoni 10, muri zo abagera kuri miliyoni 2 ni za fibrillation ya valvular na miliyoni 7 kuri fibrillation idafite agaciro.Ubushakashatsi bwakozwe mu mwaka wa 2016 Byagaragaye ko igipimo cyo kumenya fibrillation atriyale mu Bushinwa ari 40%, naho anticoagulation ni 30%.Rivaroxaban iroroshye gukoresha, ntibisaba gukurikirana buri gihe ibipimo bya coagulation, kandi igipimo cya anticoagulation nacyo kizanozwa cyane.Byahanuwe ko ibiyobyabwenge rusange byarivaroxabanazaba ari mubushinwa.Ingano yisoko ikoreshwa mubarwayi bafite fibrillation idafite agaciro na fibrillation ya atiri: abarwayi miliyoni 7 * igipimo cya anticoagulation 30% * 50% byinjira * 2.76 yuan / kumunsi * iminsi 365 = miliyoni 157.

Byongeye kandi, amahirwe yisoko yo gukumira no kuvura abarwayi ba VTE ntasuzugurwa.Dukurikije imibare y’ikigo gishinzwe gukumira no kuvura VTE muri Amerika, umubare w’abarwayi ba VTE muri Amerika ugera ku 900.000 buri mwaka, kandi umubare w’abantu bapfa bazize VTE ugera ku 60.000 kugeza 100.000, kandi hari ibibazo by'igihe kirekire (nka DVT) abarwayi bangana na 50%, naho umubare wongeye kugaruka mumyaka 10 wagize 33%.

Bitewe n'ubusaza bw'Abashinwa, kandi umubare w'abaturage urenze inshuro 4 z'Amerika (miliyari 1.395).Turashobora guhanura ko mubushinwa buri mwaka hari miliyoni 3.6 abarwayi ba VTE.Dufashe ko igipimo cyamezi 3 yo kuvura yarivaroxabanni 80%, ingano yisoko ni: miliyoni 3.6 abarwayi * 80% yo kwivuza * 2.76 yuan / kumunsi * iminsi 92 = miliyoni 731.

Kubwibyo, kubara gusa ibimenyetso bibiri bya AF na VTE, ingano yisoko ryimbere yimiti ya rivaroxaban igera kuri miliyari 2.Birahagije gutera uruganda rukora imiti murugo kwihutira gusaba kurutonde.

Twebwe,Uruganda rwa farumasi rwa Changzhou, kandiapxiabannarivaroxban, kandi byombi bifite DMF.Rivaroxabaniri gutunganywa gusaba CEP na WC.