Uyu muti ukoreshwa nabagore kugirango bafashe kugabanya ububabare buringaniye kandi bukabije kubera indwara yitwa endometriose.
Gicurasi ishobora kuvura: Endometriose
Amazina y'ibirango: Orilissa
Icyiciro cyibiyobyabwenge: LHRH (GnRH) Antagonistes
Kuboneka: Ibisabwa
Inda: Irinde gukoresha mugihe utwite
Konsa: Baza muganga mbere yo gukoresha

Elagolix ni bioavailable mu kanwa, igisekuru cya kabiri, idafite peptide ishingiye, molekile ntoya hamwe na hormone irekura imisemburo ya gonadotropine (GnRH; LHRH) reseptor antagonist, hamwe nibikorwa byo guhagarika imisemburo. Ku buyobozi bwo mu kanwa, elagolix irushanwa na GnRH kugirango ihuze reseptor kandi ikabuza reseptor ya GnRH yerekana ibimenyetso muri glande y'imbere. Ibi bibuza gusohora imisemburo ya luteinizing (LH) hamwe na misemburo itera imisemburo (FSH). Ku bagabo, kubuza gusohora LH birinda irekurwa rya testosterone. Ku bagore, kubuza FSH na LH birinda umusaruro wa estrogene na ovaries. Kubuza ibimenyetso bya GnRH birashobora kuvura cyangwa gukumira ibimenyetso byindwara ziterwa na hormone zishingiye ku mibonano mpuzabitsina.

Elagolix ni umunwa, nonaderoidal gonadotropine irekura imisemburo (GnRH) igabanya umusaruro wa estrogene kandi ikoreshwa mu kuvura uburyo bubabaza bwa endometriose ku bagore. Ubuvuzi bwa Elagolix bufitanye isano n'umuvuduko muke wa serumu enzyme yo hejuru mugihe cyo kuvura kandi ntikirahuzwa nigihe cyo gukomeretsa umwijima bigaragara.

Elagolix yakoreshejwe mu bigeragezo yiga siyanse y'ibanze no kuvura Endometriose, Folliculogenezesi, Fibroide ya Uterine, Amaraso akomeye ya Uterine, no kuva amaraso akomeye. Kugeza ku ya 24 Nyakanga 2018, ariko, Ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA) cyemeje elagolix ya AbbVie ku izina rya Orilissa nk’imisemburo ya mbere kandi yonyine yo mu kanwa ya gonadotropine irekura imisemburo (GnRH) yakozwe cyane cyane ku bagore bafite ububabare bukabije bwa endometriose. Byemejwe ko endometriose ari imwe mu ndwara z’abagore bakunze kugaragara muri Amerika. By'umwihariko, ibigereranyo byerekana ko umwe mu bagore icumi bafite imyaka yo kubyara yatewe na endometriose kandi akagira ibimenyetso bibabaza. Byongeye kandi, abagore banduye iyi ndwara barashobora kubabazwa kugeza kumyaka itandatu kugeza ku icumi kandi bagasura abaganga benshi mbere yo kwisuzumisha neza. Icyakurikiyeho, nkuko Orilissa (elagolix) yemejwe na FDA mu isuzuma ryibanze, iki cyemezo gishya cyihuse giha inzobere mu buvuzi ubundi buryo bw'ingenzi bwo kuvura ibyifuzo by’abagore badashobora kwanduzwa na endometriose, bitewe n'ubwoko bwabo n'uburemere bw'ububabare bwa endometriose. .

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