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Kalisiyumu ya Atorvastatin ni inhibitori ya HMG-CoA reductase ifite IC50 ifite agaciro ka 150 nM [1].
HMG-CoA reductase ni enzyme yingenzi yinzira ya mevalonate itanga cholesterol. HMG-CoA ni enzyme igabanya umuvuduko kandi ni ngombwa mu kugabanya urugero rwa cholesterol mu maraso. HMG-CoA reductase iherereye muri reticulum ya endoplasme kandi irimo umunani wa transembrane. Inhibitori ya HMG-CoA reductase irashobora gutuma LDL (lipoprotein nkeya) yakira mu mwijima. Bitera kongera urugero rwa catabolisme ya plasma LDL no kugabanya ubukana bwa plasma cholesterol ikaba ari ikintu cyingenzi kigena aterosklerose. HMG-CoA reductase igira uruhare runini muri synthesis ya cholesterol. HMG-CoA niyo ony intego yibiyobyabwenge bigabanya cholesterol. HMG-CoA reductase nayo ni enzyme yingenzi mugutezimbere. Igikorwa cya reductase ya HMG-CoA kijyanye na mikorobe yimuka yimuka. Kubuza ibikorwa byayo birashobora gutuma umuntu ava amaraso ava mu nda [1].
Atorvastatin ni inhibitor ya HMG-CoA reductase ifite IC50 agaciro ka 154 nM. Ni ingirakamaro mu kuvura dyslipidemiya na hypercholesterolemia [1]. Kuvura Atorvastatine kuri 40 mg bigabanya cholesterol yose ya 40% nyuma yiminsi 40. [1] Irakoreshwa kandi mu kuvura abarwayi ba coronari cyangwa stroke bafite urugero rwa cholesterol isanzwe. Atorvastatin igabanya kandi ubucucike buke bwa lipoprotein apheresis mu barwayi itera LDL-reseptors imvugo.
Ihindurwamo metabolite nyinshi zingirakamaro mugikorwa cyibikorwa byo kuvura byakozwe na CYP3A4 (cytochrome P450 3A4). [3]
Reba:
[1]. van Dam M, Zwart M, de Beer F, Smelt AH, Prins MH, Urugendo MD, Havekes LM, Lansberg PJ, Kastelein JJ: Ingaruka ndende n’umutekano wa atorvastatine mu kuvura ubwoko bukomeye bwa III hamwe na dyslipidaemia. Umutima 2002, 88 (3): 234-238.
[2]. Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT et al: Kwirinda ibintu bya koronari na stroke hamwe na atorvastatine mubarwayi bafite umuvuduko ukabije bafite impuzandengo cyangwa munsi-munsi -ikigereranyo cya cholesterol yibitseho, muri Anglo-Scandinaviya Yumutima Yumutima - Lipid Lowering Arm (ASCOT-LLA): igeragezwa ryinshi ryateganijwe. Lancet 2003, 361 (9364): 1149-1158.
[3]. Lennernas H: Pharmacokinetics ya Clinical ya atorvastatin. Clin Pharmacokinet 2003, 42 (13): 1141-1160.

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