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Kalisiyumu ya Atorvastatine ni inhibitori ya HMG-CoA reductase ifite IC50 agaciro ka 150 nM [1].
HMG-CoA reductase ni enzyme yingenzi yinzira ya mevalonate itanga cholesterol.HMG-CoA ni enzyme igabanya umuvuduko kandi ni ngombwa mu kugabanya urugero rwa cholesterol mu maraso.HMG-CoA reductase iherereye muri endoplasmic reticulum kandi irimo umunani wa transembrane.Inhibitori ya HMG-CoA reductase irashobora gutuma LDL (lipoprotein nkeya) yakira umwijima.Bitera kongera catabolisme ya plasma LDL no kugabanya ubukana bwa plasma cholesterol ikaba ari ikintu cyingenzi kigena aterosklerose.HMG-CoA reductase igira uruhare runini muri synthesis ya cholesterol.HMG-CoA niyo ntego ya imiti igabanya cholesterol.HMG-CoA reductase nayo ni enzyme yingenzi mugutezimbere.Igikorwa cya reductase ya HMG-CoA ifitanye isano nudukoko twimuka twimuka.Kubuza ibikorwa byayo birashobora gutuma umuntu ava amaraso ava mu nda [1].
Atorvastatin ni HMG-CoA reductase inhibitor ifite IC50 agaciro ka 154 nM.Ni ingirakamaro mu kuvura dyslipidemiya na hypercholesterolemia [1].Kuvura Atorvastatine kuri mg 40 bigabanya cholesterol ya 40% nyuma yiminsi 40. [1]Irakoreshwa kandi mu kuvura abarwayi ba coronary cyangwa stroke bafite cholesterol isanzwe.Atorvastatin igabanya kandi ubucucike buke bwa lipoprotein apheresis kubarwayi itera LDL-reseptors imvugo.
Ihindurwamo metabolite nyinshi zingirakamaro kubikorwa byubuvuzi na CYP3A4 (cytochrome P450 3A4). [3]
Reba:
[1].van Dam M, Zwart M, de Beer F, Smelt AH, Prins MH, Urugendo MD, Havekes LM, Lansberg PJ, Kastelein JJ: Ingaruka ndende n’umutekano wa atorvastatine mu kuvura ubwoko bukomeye bwa III hamwe na dyslipidaemia.Umutima 2002, 88 (3): 234-238.
[2].Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT nibindi: Kwirinda ibintu bya coronary na stroke hamwe na atorvastatin mubarwayi bafite hypertension bafite impuzandengo cyangwa munsi-munsi. -kugabanya ubukana bwa cholesterol, muri Anglo-Scandinaviya Yumutima Yumutima - Lipid Lowering Arm (ASCOT-LLA): ikigeragezo cyateganijwe.Lancet 2003, 361 (9364): 1149-1158.
[3].Lennernas H: Pharmacokinetics ya Clinical ya atorvastatin.Clin Pharmacokinet 2003, 42 (13): 1141-1160.

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